Results 71 to 80 of about 579,721 (281)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Numerical Modeling of Extreme Sea Levels on the Laptev Sea Coast

Geosciences
The present study is devoted to the analysis of extreme sea level oscillations of the Laptev Sea using the ADCIRC model. The numerical modeling is performed on a high-resolution grid and verified for sea level observations from three tide gauges. We have
Mikhail E. Kulikov, Victor S. Arkhipkin, Igor P. Medvedev, Sergey A. Kovachev, Artem A. Krylov   +4 more
doaj   +1 more source

Automated tail-informed threshold selection for extreme coastal sea levels [PDF]

Natural Hazards and Earth System Sciences
Peaks over threshold (POT) techniques are commonly used in practice to model tail behaviour of univariate variables. The resulting models can be used to aid in risk assessments, providing estimates of relevant quantities such as return levels and periods.
T. P. Collings, C. J. R. Murphy-Barltrop, C. J. R. Murphy-Barltrop, C. Murphy, I. D. Haigh, I. D. Haigh, P. D. Bates, P. D. Bates, N. D. Quinn   +8 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Wind and Wave Setup Contributions to Extreme Sea Levels at a Tropical High Island: A Stochastic Cyclone Simulation Study for Apia, Samoa

Journal of Marine Science and Engineering, 2015
Wind-wave contributions to tropical cyclone (TC)-induced extreme sea levels are known to be significant in areas with narrow littoral zones, particularly at oceanic islands. Despite this, little information exists in many of these locations to assess the
Ron Karl Hoeke, Kathleen L. McInnes, Julian G. O’Grady   +2 more
doaj   +1 more source

A multidisciplinary coastal vulnerability assessment for local government focused on ecosystems, Santa Barbara area, California [PDF]

, 2019
Incorporating coastal ecosystems in climate adaptation planning is needed to maintain the well-being of both natural and human systems. Our vulnerability study uses a multidisciplinary approach to evaluate climate change vulnerability of an urbanized ...
Myers, Monique
core  

Assessment and comparison of extreme sea levels and waves during the 2013/14 storm season in two UK coastal regions [PDF]

, 2015
The extreme sea levels and waves experienced around the UK's coast during the 2013/14 winter caused extensive coastal flooding and damage. Coastal managers seek to place such extremes in relation to the anticipated standards of flood protection, and the ...
Brown, J.M., Dolphin, T., Haigh, I.D., Wadey, M.P., Wisse, P.   +4 more
core   +3 more sources

Extreme Sea Level Estimation Combining Systematic Observed Skew Surges and Historical Record Sea Levels

Water Resources Research, 2022
AbstractThe estimation of sea levels corresponding to high return periods is crucial for coastal planning and for the design of coastal defenses. This paper deals with the use of historical observations, that is, events that occurred before the beginning of the systematic tide gauge recordings, to improve the estimation of design sea levels.
Laurie Saint Criq, Eric Gaume, Yasser Hamdi, Taha B. M. J. Ouarda   +3 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Recent Change—North Sea [PDF]

, 2016
This chapter discusses past and ongoing change in the following physical variables within the North Sea: temperature, salinity and stratification; currents and circulation; mean sea level; and extreme sea levels.
Colijn, F, Haigh, I, Hjøllo, S, Holfort, J, Huthnance, JM, Kent, EC, Kühn, W, Loewe, P, Lorkowski, I, Mork, KA, Pietrzak, J, Pätsch, J, Quante, M, Salt, L, Schmelzer, N, Siddorn, JR, Smyth, TJ, Souza, AJ, Sterl, A, Thomas, H, van Beusekom, JEE, van Heteren, S, Wahl, T, Weisse, R, Woodworth, P   +24 more
core   +1 more source