Results 81 to 90 of about 579,721 (281)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
HadISD: a quality-controlled global synoptic report database for selected variables at long-term stations from 1973--2011 [PDF]
, 2012 [Abridged] This paper describes the creation of HadISD: an automatically quality-controlled synoptic resolution dataset of temperature, dewpoint temperature, sea-level pressure, wind speed, wind direction and cloud cover from global weather stations for ...
Dai, Aiguo +7 more
core +4 more sources
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Climate change exacerbates hurricane flood hazards along US Atlantic and Gulf Coasts in spatially varying patterns [PDF]
, 2020 One of the most destructive natural hazards, tropical cyclone (TC)–induced coastal flooding, will worsen under climate change. Here we conduct climatology–hydrodynamic modeling to quantify the effects of sea level rise (SLR) and TC climatology change ...
Emanuel, Kerry
core +1 more source
Water level response in back-barrier bays unchanged following Hurricane Sandy [PDF]
, 2014 © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Geophysical Research Letters 41 (2014): 3163–3171, doi:10.1002/2014GL059957.On 28–30 October 2012 ...
Aretxabaleta, Alfredo L. +2 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
An investigation of recent decadal-scale storm events in the Eastern Irish Sea [PDF]
, 2010 The Proudman Oceanographic Laboratory Coastal Modelling System coupled to the WAve Model (POLCOMS-WAM) modeling system has been used to model combined tides, surges, waves, and wave-current interaction in the Irish Sea on a 1.85 km grid.
Brown, Jennifer M. +2 more
core +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source