Results 51 to 60 of about 252,784 (258)

PROPERTIES OF SELECTED SIGNIFICANCE TESTS FOR EXTREME VALUE INDEX

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2014
The paper presents two tests verifying the hypothesis about the shape parameter of the generalized distribution of maximum statistic. It is called the extreme value index.
Dorota Pekasiewicz
doaj  

Extremal Trees for Logarithmic VDB Topological Indices

open access: yesAxioms
Vertex-degree-based (VDB) topological indices have been applied in the study of molecular structures and chemical properties. At present, the exponential VDB index has been studied extensively.
Zhenhua Su, Hanyuan Deng
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Heuristic Tools for the Estimation of The Extremal Index

open access: yesRevstat Statistical Journal, 2018
Clustering of exceedances of a critical level is a phenomenon that concerns risk managers in many areas. The extremal index θ measures the propensity of the large observations in a dataset to cluster.
Marta Ferreira
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Extreme Body Condition Index Values in Small Mammals

open access: yesLife
The body condition index (BCI) values in small mammals are important in understanding their survival and reproduction. The upper values could be related to the Chitty effect (presence of very heavy individuals), while the minimum ones are little known.
Linas Balčiauskas   +1 more
openaire   +4 more sources

Single-index models for extreme value index regression

open access: yes, 2022
Abstract Since the extreme value index (EVI) controls the tail behaviour of the distribution function, the estimation of EVI is a very important topic in extreme value theory. Recent developments in the estimation of EVI along with covariates have been in the context of nonparametric regression.
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The generalization of several classical estimators for a positive extreme value index

open access: yesModern Stochastics: Theory and Applications
In this paper, we introduce a family of semi-parametric estimators for the positive extreme value index γ, parameterized in two tuning parameters. The asymptotic normality of the introduced estimators is proved. It is shown that the partial case of newly
Marijus Vaičiulis
doaj   +1 more source

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