Results 41 to 50 of about 1,039,132 (290)
Principle extremum of full action in electrodynamic
Here we are going to formulate and prove variational extremum principle for electrodynamics, asserting that there exists a functional that depends on powers.
Solomon Khmelnik
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An extremum variational principle for a class of boundary value problems [PDF]
A variational principle for a class of Hamiltonian boundary value problems is formulated. Conditions under which it possesses an extremum (maximum or minimum) are examined and error bounds for approximate solutions are derived.
Atanackovic, T.M, Djukic, Dj.S
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Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
It is shown by finite element modeling that under high-pressure torsion of water-atomized pure iron powder a zone with high shear strain and high density develops first in a layer adjacent to the moving anvil. The finite element simulation results and an
Roman Kulagin +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
In the theory of mixed-type equations, most studies have been carried out for bounded domains with smooth boundaries and for equations of the first kind.
Zunnunov, R.T. +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Error bounds via a new extremum variational principle, mean square residual and weighted mean square residual [PDF]
Error bounds for a wide class of nonlinear one-dimensional boundary value problems are derived from a new extremum variational principle. A new least-squares approximate technique, based on a weighted mean square residual, is established. Also, the value
Atanackovic, T.M, Djukic, Dj.S
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‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
In this paper, the Tricomi problem for a second-kind mixed-type equation with a lower-order term is studied in an unbounded domain. The elliptic part of the domain is a vertical half-strip, while the hyperbolic part is bounded by characteristics ...
Rakhimjon Zunnunov +2 more
doaj +1 more source

