Results 51 to 60 of about 3,166 (214)

Telomerase modRNA Offers a Novel RNA‐Based Approach to Treat Human Pulmonary Fibrosis

Aging Cell, Volume 24, Issue 11, November 2025.
Recombinant linear and circular hTERT mRNA restore telomerase activity in primary ATII cells and ex vivo lung tissue from patients with pulmonary fibrosis, leading to telomere elongation, reduced DNA damage, and decreased senescence and fibrosis markers.
Jia Li Ye, Klaudia Grieger, Dongchao Lu, Christina Brandenberger, Malte Juchem, Maria Jordan, Lea Oehlsen, Patrick Zardo, Christopher Werlein, Christina Hesse, Katherina Sewald, Sandy Tretbar, Thomas Thum, Shambhabi Chatterjee, Christian Bär   +14 more
wiley   +1 more source

BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis

Mediators of Inflammation, 1998
Several lines of research indirectly suggest that platelet activating factor (PAF) may intervene in the pathogenesis of extrinsic allergic alveolitis (EAA).
J-L. Pérez-Arellano, T. Martón, J-M. López-Novoa, M-L. Sánchez, A. Montero, A. Jiménez   +5 more
doaj   +1 more source

Comorbidities and survival in patients with chronic hypersensitivity pneumonitis

Respiratory Research, 2020
Introduction Chronic Hypersensitivity Pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from repeated exposure to an offending antigen.
Julia Wälscher, Benjamin Gross, Julie Morisset, Kerri A. Johannson, Martina Vasakova, Jacques Bruhwyler, Michael Kreuter   +6 more
doaj   +1 more source

Acute life-threatening extrinsic allergic alveolitis in a paint controller [PDF]

, 2017
Background Occupational diisocyanate-induced extrinsic allergic alveolitis (EAA) is a rare and probably underestimated diagnosis. Two acute occupational EAA cases have been described in this context, but neither of them concerned hexamethylene ...
Bieler, G., Danuser, B., Huynh, C. K., Steiner, U.-C, Thorn, D., Tomicic, C., Yawalkar, N.   +6 more
core  

Respiratory Ill‐Health and Welding Exposures: A Canadian Cohort Study

American Journal of Industrial Medicine, Volume 68, Issue 2, Page 99-111, February 2025.
ABSTRACT Introduction Respiratory ill‐health in welders is well documented but without a clear indication of exposures responsible. Methods In a Canadian cohort study of welders and electrical workers, we collected self‐reports of asthma/wheeze and rhinitis at each 6‐monthly contact for up to 5 years.
Jean‐Michel Galarneau, Jeremy Beach, Nicola Cherry   +2 more
wiley   +1 more source

Diagnosis and management of hypersensitivity pneumonitis in adults: A position statement from the Thoracic Society of Australia and New Zealand

Respirology, Volume 29, Issue 12, Page 1023-1046, December 2024.
Abstract Hypersensitivity pneumonitis (HP) is an immune‐mediated interstitial lung disease (ILD) relating to specific occupational, environmental or medication exposures. Disease behaviour is influenced by the nature of exposure and the host response, with varying degrees of lung inflammation and fibrosis seen within individuals. The differentiation of
Hayley Barnes, Tamera J. Corte, Gregory Keir, Yet H. Khor, Sandhya Limaye, Jeremy P. Wrobel, Elizabeth Veitch, John Harrington, Leona Dowman, Lutz Beckert, David Milne, Rebekah De Losa, Wendy A. Cooper, Peter T. Bell, Pradeep Balakrishnan, Lauren K. Troy   +15 more
wiley   +1 more source

Incidence, Prevalence, and Survival of Patients with Idiopathic Pulmonary Fibrosis in the UK. [PDF]

, 2018
INTRODUCTION: Recent developments in the care of patients with idiopathic pulmonary fibrosis have the potential to improve survival rates. Population-based estimates of the current disease burden are needed to evaluate the future impact of newly approved
Kausar, Imran, Maher, Toby M, Strongman, Helen   +2 more
core   +3 more sources

Bidirectional transfer of human cytomegalovirus strains in donor and recipient seropositive lung transplant patients

Journal of Medical Virology, Volume 96, Issue 7, July 2024.
Abstract Donor and recipient human cytomegalovirus (HCMV) seropositive (D+R+) lung transplant recipients (LTRs) often harbor multiple strains of HCMV, likely due to transmitted donor (D) strains and reactivated recipient (R) strains. To date, the extent and timely occurrence of each likely source in shaping the post‐transplantation (post‐Tx) strain ...
Büsra Külekci, Madlen Mollik, Stefan Schwarz, Nicole Perkmann‐Nagele, Silvana Geleff, Peter Jaksch, Konrad Hoetzenecker, Christopher Lambers, Elisabeth Puchhammer‐Stöckl, Irene Goerzer   +9 more
wiley   +1 more source

Autoimmune Hypothyroidism As a Predictor of Mortality in Chronic Hypersensitivity Pneumonitis

Frontiers in Medicine, 2017
BackgroundChronic hypersensitivity pneumonitis (CHP) is a fibrotic parenchymal lung disease that occurs when inhalation of environmental antigens leads to immune dysregulation.
Ayodeji Adegunsoye, Justin M. Oldham, Aliya N. Husain, Lena Chen, Scully Hsu, Steven Montner, Jonathan H. Chung, Rekha Vij, Imre Noth, Mary E. Strek   +9 more
doaj   +1 more source

Fibrotic lung diseases in children

Pediatric Pulmonology, Volume 59, Issue 5, Page 1165-1174, May 2024.
Abstract In children, pulmonary fibrosis (PF) is an extremely unusual entity that can be observed in some types of interstitial lung disease (ILD). Defining whether ILD is accompanied by PF is important for targeted therapy. Algorithm for the diagnosis of PF in children is not clearly established.
Birce Sunman, Nural Kiper
wiley   +1 more source