Results 41 to 50 of about 310,806 (291)

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

Oxidative Medicine and Cellular Longevity, 2016
The reactive oxygen species (ROS) form under normal physiological conditions and may have both beneficial and harmful role. We search the literature and current knowledge in the aspect of ROS participation in the pathogenesis of anterior and posterior ...
M. Nita, A. Grzybowski
semanticscholar   +1 more source

The Use of AAV Vector-based Gene Therapy in the Treatment of Ophthalmic Diseases. Literature Review

Oftalʹmologiâ
Introduction. This review article is devoted to the study of the current state of gene therapy using adeno-associated viruses (AAV) in the treatment of ophthalmic diseases.Objective: The purpose: to evaluate the effectiveness and safety of using gene ...
Z. A. Batyrova, A. Sh. Murtazalieva, J. M. Ramazanova, A. S.‑U. Batchaev   +3 more
doaj   +1 more source

Spontaneous dislocation of a transparent lens to the anterior chamber: A case report [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. The causes leading to dislocation of the natural lenses are different involving injuries, hereditary diseases and spontaneous dislocation.
Jovanović Miloš, Stefanović Ivan
doaj   +1 more source

A History of Dystonia: Ancient to Modern [PDF]

, 2017
Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to ...
Deborah Thorpe, Jane Alty, Peter Kempster, Rachel Newby   +3 more
core   +1 more source

Retinopathy as an initial sign of hereditary immunological diseases: report of six families and challenges in eye clinic

Frontiers in Immunology, 2023
IntroductionRetinal degenerative or inflammatory changes may occur with hereditary immunological disorders (HID) due to variants in approximately 20 genes.
Yingwei Wang, Yi Jiang, Junwen Wang, Shiqiang Li, Xiaoyun Jia, Xueshan Xiao, Wenmin Sun, Panfeng Wang, Qingjiong Zhang   +8 more
doaj   +1 more source

Sleep Disorders Associated with Neurodegenerative Diseases

Diagnostics, 2023
Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington’s disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy ...
Lucreția Anghel, A. Ciubara, A. Nechita, L. Nechita, Corina Manole, Liliana Baroiu, A. B. Ciubară, C. Musat   +7 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Spinocerebellar Ataxia Type 2 [PDF]

, 2012
1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections.
Auburger, Georg, Freund, Hans-Joachim, Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis   +3 more
core   +1 more source

Cyclosporine A does not prevent second-eye involvement in Leber’s hereditary optic neuropathy

Orphanet Journal of Rare Diseases, 2018
BackrgroundEvaluation of the efficacy of oral cyclosporine A as a prophylactic agent in preventing second-eye involvement in Leber’s hereditary optic neuropathy (LHON) in a prospective, open-label, non-randomized, multicenter pilot study.
S. Leruez, C. Verny, D. Bonneau, V. Procaccio, G. Lenaers, P. Amati‐Bonneau, P. Reynier, C. Scherer, Adriana Prundean, C. Orssaud, X. Zanlonghi, M. Rougier, C. Tilikete, D. Milea   +13 more
semanticscholar   +1 more source