Results 41 to 50 of about 454,365 (249)

Efficacy and safety of the initial hypotensive treatment with an optimized latanoprost composition

Российский офтальмологический журнал, 2023
Purpose: a comparative study of the efficacy and safety of Latanoprost-Optic, a new composition of excipients and the original latanoprost, in the initial therapy of primary open-angle glaucoma (POAG)Material and methods.
S. Yu. Petrov, E. V. Yani, A. N. Zhuravleva, O. M. Filippova, O. M. Kalinina, L. V. Yakubova, S. M. Kosakyan, L. V. Vasilenkova, I. V. Manukyan   +8 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Acoustic density of the sclera of keratoconus eyes and its clinical significance

Российский офтальмологический журнал, 2023
Purpose: to assess the biophysical properties of the sclera by measuring its acoustic density in keratoconus, highly myopic, and healthy eyes. Material and methods.
E. P. Tarutta, A. T. Khandzhyan, T. N. Kiseleva, S. V. Milash, A. V. Ivanova, O. V. Guryanova, G. A. Markosyan, A. N. Bedretdinov, K. A. Ramazanova   +8 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Fungal corneal ulcer complicated by endophthalmitis: clinical and laboratory diagnostics, treatment tactics

Российский офтальмологический журнал, 2022
Purpose: to study the clinical signs and effectiveness of laboratory diagnostics of fungal corneal ulcer complicated by endophthalmitis aimed at treatment tactics optimization.Materials and methods.
L. A. Kovaleva, G. I. Krichevskaya, P. V. Maкarov, A. O. Petrova, S. V. Flora, I. D. Zyurnyayeva, A. E. Andryushi, O. I. Markelova   +7 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

COMPARISON OF CLINICAL AND REAL-LIFE TRiaLS OF THE EFFECTIVENESS OF ANTI-VEGF THERAPY FOR age-related macular degeneration

Сибирский научный медицинский журнал, 2019
In recent years, the approaches to assessing results have been changed in both clinical and real life trials with the introduction of Aflibercept to clinical practice.
M. V. Budzinskaya, A. A. Plyukhova, A. V. Shelankova, A. V. Kuznetsov, I. V. Andreeva   +4 more
doaj   +1 more source

Efficacy of artificial tears containing trehalose and hyaluronic acid for dry eye disease in women aged 42–54 versus ≥ 55 years [PDF]

, 2023
Antonio J. Mateo-Orobia, Eduardo del Prado Sanz, Alejandro Blasco‐Martinez, Luís E. Pablo, Sarah Farrant, Frédéric Chiambaretta   +5 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Diamond Burr Polishing of Bowman’s Layer in the Treatment of Subepithelial Fibrosis after Radial Keratotomy (Clinical Case)

Oftalʹmologiâ, 2019
Radial keratotomy (RK) was widely used at the end of the last century for refractive purposes. However, ophthalmologists are increasingly faced with negative long-term consequences after RK now.
S. V. Trufanov, L. Yu. Tekeeva, M. A. Makarova, N. P. Shahbazyan   +3 more
doaj   +1 more source