Results 51 to 60 of about 3,320,084 (298)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Eye-hand coordination during visual search on geographic displays [PDF]

, 2014
This work is supported by the Royal Society grant IE120643. The authors thank Floris Heim from University of Zurich for data collection. JV and UD are supported by the EU FP7 Marie Curie ITN GEOCROWD (FP7-PEOPLE-2010-ITN-264994)Eye movement analysis can ...
Demsar, Urska, Çöltekin, A., Brychtová, A., Vandrol, J.   +3 more
core   +3 more sources

Eye Movements in Neurology [PDF]

, 2019
Eye movement disorders play an important role in clinical neurology, since they are part of many neurological diseases. Furthermore, from a scientific point of view, the assessment of the patterns of eye movement disturbances after focal brain lesions is
Müri, René Martin, Nyffeler, Thomas, Cazzoli, Dario   +2 more
core   +2 more sources

Effectiveness and safety of hypotensive therapy of primary glaucoma with a Russian generic fixed combination of dorzolamide and timolol

Российский офтальмологический журнал, 2022
Purpose: a comparative study of the efficacy and safety of the generic drug Dorzial Plus, an analogue of the original reference drug Cosopt®, in patients with primary open-angle glaucoma (POAG).Material and methods. The study involved 80 patients of both
S. Yu. Petrov, O. M. Kalinina, A. N. Zhuravleva, O. M. Filippova, L. V. Yakubova, L. V. Vasilenkova, S. M. Kosakyan, O. I. Markelova   +7 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

COMPARISON OF CLINICAL AND REAL-LIFE TRiaLS OF THE EFFECTIVENESS OF ANTI-VEGF THERAPY FOR age-related macular degeneration

Сибирский научный медицинский журнал, 2019
In recent years, the approaches to assessing results have been changed in both clinical and real life trials with the introduction of Aflibercept to clinical practice.
M. V. Budzinskaya, A. A. Plyukhova, A. V. Shelankova, A. V. Kuznetsov, I. V. Andreeva   +4 more
doaj   +1 more source

Adjunctive antihypertensive therapy of primary glaucoma with a fixed combination drug of 1% brinzolamide and 0.5% timolol: efficacy and safety

Российский офтальмологический журнал, 2023
Purpose: a comparative study of the efficacy and safety of the combination drug Brinzopt Plus and the original drug Azarga used as adjunctive therapy in patients with primary open-angle glaucoma (POAG) previously treated with latanoprost.Material and ...
S. Yu. Petrov, O. M. Kalinina, L. V. Yakubova, S. M. Kosakyan, L. V. Vasilenkova, O. M. Filippova, A. N. Zhuravleva, O. I. Markelova   +7 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Multifunctional Protein Alpha2-Macroglobulin in Tear Fluid and Blood Serum of Patients with Glaucoma

Oftalʹmologiâ, 2023
Alpha2-macroglobulin (α2-MG) is a multifunctional glycoprotein. Due to the variety of its functions there can be several ways of its involvement in the pathogenesis of the glaucomatous optic neuropathy, including neuroinflammation, amyloid deposition ...
N. B. Chesnokova, T. A. Pavlenko, O. V. Beznos, S. Yu. Petrov, A. M. Bessmertny, O. M. Filippova, O. M. Kalinina, V. I. Kotelin   +7 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source