Validation of the OptiSafe™ eye irritation test. [PDF]
Cutan Ocul Toxicol, 2020 OptiSafe is an in chemico test method that identifies potential eye irritants based on macromolecular damage following test chemical exposure. The OptiSafe protocol includes a prescreen assessment that identifies test chemicals that are outside the applicability domain of the test method and thus determines the optimal procedure.
Choksi N +13 more
europepmc +6 more sources
Tissue Engineered Mini-Cornea Model for Eye Irritation Test. [PDF]
Tissue Eng Regen Med, 2023 Eye irritation tests with animals have been conducted for a long time. However, the subjective decision to irritation, the anatomic/physiologic difference between species and humans, and ethical issues are crucial problems. Various research groups have paid attention to alternative testing methods.
Kim SH, Jo SH, Kim BK, Park SH.
europepmc +5 more sources
Development of an Eye Irritation Test Method Using an In-House Fabrication of a Reconstructed Human Cornea-like Epithelium Model for Eye Hazard Identification [PDF]
BioengineeringIn a previous study, a novel human corneal-like epithelium model utilizing an immortalized human corneal epithelial cell line (iHCE-NY1) was developed as an alternative to animal models to identify chemicals not classified under the United Nations ...
Naoki Yamamoto +4 more
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Laser Light-Based Opacitometer ‘Peira LLBO 180’: A new and validated opacitometer for use in the Bovine Corneal Opacity and Permeability (BCOP) eye irritation test method [PDF]
MethodsX, 2020 The “Peira LLBO 180” is a Laser Light-Based Opacitometer that can be used as an alternative for the standard OP-KIT device in the Bovine Corneal Opacity and Permeability (BCOP) test Organisation for Economic Co-operation and Development (OECD) Test ...
An R. Van Rompay +2 more
doaj +3 more sources
Eye Irritation Test of Soyeom Pharmacopuncture Solution for Eye Drop
Journal of Pharmacopuncture, 2008 Objectives : This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
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Eye Irritation Test of Fel Ursi & Bovis Calculus Pharmacopuncture Solutions for Eye Drop
Journal of Pharmacopuncture, 2008 Objective : This study was done to investigate the safety of Fel Ursi & Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods : The eye irritation test of this material was performed according to the
Hyeong-sik Seo
doaj +5 more sources
Eye Irritation Test of Fel Ursi Pharmacopuncture Solutions for Eye Drop
Journal of Pharmacopuncture, 2008 Objective : This study was done to investigate the safety of Fel Ursi pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
doaj +3 more sources
Determination of eye irritation potential of low-irritant products: comparison of in vitro results with the in vivo draize rabbit test [PDF]
Brazilian Archives of Biology and Technology, 2012 In an attempt to build the evaluation strategies to assess the human eye irritation, a reassessment of some in vitro tests is necessary, particularly concerning the non-irritants, mild and moderate irritants.
Andréa Martins da Nóbrega +4 more
doaj +2 more sources
Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay. [PDF]
Part Fibre Toxicol, 2016 Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce. Traditionally, eye irritation testing was performed using rabbits. The OECD Test Guideline 437 Bovine Corneal Opacity and Permeability (BCOP) test method allows
Kolle SN +5 more
europepmc +4 more sources
Alternative methods for the replacement of eye irritation testing
ALTEX, 2015 In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test has been criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize ...
Christian Lotz
openalex +5 more sources