Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay [PDF]
Part Fibre Toxicol, 2015 Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focussing on the eye damaging potential of nanomaterials are scarce.
Susanne N. Kolle +5 more
europepmc +3 more sources
Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model [PDF]
J Vis Exp, 2015 To comply with the Seventh Amendment to the EU Cosmetics Directive and EU REACH legislation, validated non-animal alternative methods for reliable and accurate assessment of ocular toxicity in man are needed.
Yulia Kaluzhny +4 more
europepmc +3 more sources
Impact of Latanoprost Antiglaucoma Eyedrops and Their Excipients on Toxicity and Healing Characteristics in the Ex Vivo Eye Irritation Test System. [PDF]
Ophthalmol Ther, 2023 Corneal epithelial toxicity and delayed healing process have already been attributed to preservatives or some excipients. We study the effects of galenic components in antiglaucoma drugs such as benzalkonium chloride (BAC) or surfactants like ...
Panfil C +5 more
europepmc +2 more sources
Modeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe). [PDF]
Toxicol In Vitro, 2021 Lebrun SJ +4 more
europepmc +2 more sources
Impedance-based in vitro eye irritation testing enables the categorization of diluted chemicals
Scientific ReportsProducts containing chemicals with eye irritation potential need to be labeled with the respective hazard symbol. To avoid the testing of numerous dilutions of chemicals on animals, their labeling is directed by a theoretical approach.
H. Weissinger +3 more
doaj +2 more sources
The EpiOcular Eye Irritation Test (EIT) for Hazard Identification and Labelling of Eye Irritating Chemicals: Protocol Optimisation for Solid Materials and the Results after Extended Shipment [PDF]
Alternatives to laboratory animals : ATLA, 2015 Yulia Kaluzhny +8 more
openalex +2 more sources
Test No. 405: Acute Eye Irritation/Corrosion [PDF]
OECD Guidelines for the Testing of Chemicals, Section 4, 2012 Organisation for Economic Co-operation and Development
openalex +2 more sources
Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation [PDF]
Scientific Reports, 2018 Highly invasive animal based test procedures for risk assessment such as the Draize eye test are under increasing criticism due to poor transferability for the human organism and animal-welfare concerns.
Christian Lotz +5 more
openalex +2 more sources
Shanghai yufang yixue, 2022 ObjectiveTo establish bovine corneal opacity and permeability （BCOP） test， and determine its predictive ability for the eye irritation evaluation of cosmetics.MethodsA total of ten reference chemicals were selected to establish the BCOP test.
HUO Qian +8 more
doaj +1 more source
Influence of Corneal Staining in Rabbits on the Evaluation of Eye Irritation Test Results
Shiyan dongwu yu bijiao yixue, 2023 Objective To observe the influence of the staining phenomenon after fluorescein sodium staining on eye irritation in normal rabbits. Methods In the experimental rabbit eye irritation test conducted with sodium chloride eye drops, Siwei Zhenceng ...
XU Honghua +6 more
doaj +1 more source