Impedance-based in vitro eye irritation testing enables the categorization of diluted chemicals [PDF]
Scientific ReportsProducts containing chemicals with eye irritation potential need to be labeled with the respective hazard symbol. To avoid the testing of numerous dilutions of chemicals on animals, their labeling is directed by a theoretical approach.
H. Weissinger +3 more
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United States regulatory requirements for skin and eye irritation testing [PDF]
Cutaneous and Ocular Toxicology, 2018 Eye and skin irritation test data are required or considered by chemical regulation authorities in the United States to develop product hazard labelling and/or to assess risks for exposure to skin- and eye-irritating chemicals. The combination of animal welfare concerns and interest in implementing methods with greater human relevance has led to the ...
Neepa Choksi +14 more
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Eye Irritation Test of Bovis Calculus Pharmacopuncture Solutions for Eye Drop
Journal of Pharmacopuncture, 2008 Objective : This study was done to investigate the safety of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop.
Hyeong-sik Seo
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Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium [PDF]
Environmental Health and Toxicology, 2019 Disinfectants including polyhexamethylene guanidine phosphate (PHMG) and mixtures of chloromethylisothiazolinone/ methylisothiazolinone (CMIT/MIT) have been widely used in Korea to prevent microbial growth in the humidifier water, which triggered an ...
Juyoung Park, Handule Lee, Kwangsik Park
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Ascorbic acid specifically reduces the misclassification of nonirritating reactive chemicals in the OptiSafe™ macromolecular eye irritation test. [PDF]
Toxicol In Vitro, 2022 Lebrun S +4 more
europepmc +3 more sources
Validation study on the Ocular Irritection® assay for eye irritation testing
Toxicology in Vitro, 2014 Both a prospective and a retrospective validation study were undertaken to assess the suitability of the Ocular Irritection assay to discriminate ocular hazards as defined by the OECD and UN Globally Harmonized System (UN GHS) for classification. The primary focus of the study was to evaluate the usefulness of the Ocular Irritection assay to reliably ...
Chantra Eskes +10 more
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Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods [PDF]
, 2013 For more than two decades, scientists have been trying to replace the regulatory in vivo Draize eye test by in vitro methods, but so far only partial replacement has been achieved.
Els Adriaens +11 more
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Modeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe). [PDF]
Toxicol In Vitro, 2021 Lebrun SJ +4 more
europepmc +3 more sources
Rabbit Eye Irritation Tests of Pharmaceutical Intermediates [PDF]
Journal of the American College of Toxicology, 1992 Charissa O'Neal +2 more
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Skin and Eye Irritation Tests on Chloroform [PDF]
Journal of the American College of Toxicology, 1992 Guido A. Jacobs, Mark A. Martens
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