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Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing

Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
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Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals

Toxicology in Vitro, 2008
A previous 'in house' validation study showed that the SMI assay can be used as an alternative to the in vivo Draize eye irritation test. The aim of this multi-centre study with four participating laboratories was to assess the transferability and inter-laboratory variability of the assay using 20 reference chemicals covering the whole irritancy range.
E Adriaens, G Schoeters, J P Remon
exaly   +3 more sources

Scoring for eye irritation tests

Food and Chemical Toxicology, 1993
Scoring of the rabbit eye test and the resulting evaluation and classification should provide useful information about the likelihood that a test material may cause injury on contact with the human eye. When an animal test is necessary, a rabbit eye test based on the following characteristics is proposed for deriving the maximum information from the ...
W.A. Chambers, S. Green, K.C. Gupta, R.N. Hill, K. Huntley, P.M. Hurley, L.A. Lambert, C.C. Lee, J.K. Lee, P.T. Liu, D.K. Lowther, C.D. Roberts, V.M. Seabaugh, J.A. Springer, N.L. Wilcox   +14 more
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Recent Progress in the Eye Irritation Test

Toxicology and Industrial Health, 1993
The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in the number of animals and a ...
I H, Chu, P, Toft
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The Ex Vivo Eye Irritation Test as an Alternative Test Method for Serious Eye Damage/Eye Irritation

Alternatives to Laboratory Animals, 2015
Ocular irritation testing is a common requirement for the classification, labelling and packaging of chemicals (substances and mixtures). The in vivo Draize rabbit eye test (OECD Test Guideline 405) is considered to be the regulatory reference method for the classification of chemicals according to their potential to induce eye injury.
Felix, Spöler, Oya, Kray, Stefan, Kray, Claudia, Panfil, Norbert F, Schrage   +4 more
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Refinement of the Slug Mucosal Irritation test as an alternative screening test for eye irritation

Toxicology in Vitro, 2005
The objective of this study was to limit the test procedure time of the Slug Mucosal Irritation test to one day and to determine whether it is a relevant and reliable method to predict the eye irritation potential of chemicals. The irritation potential of several eye reference chemicals can be estimated by the amount of mucus produced when tested at a ...
E, Adriaens, M M M, Dhondt, J P, Remon
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Criteria for in vitro alternatives for the eye irritation test

Food and Chemical Toxicology, 1993
A proposal encompassing considerations and criteria for the development of in vitro alternatives to the eye irritation test has been developed and is presented here. Two factors need to be considered initially in developing an alternative test. The first is to determine whether the alternative assay is to be used as a screen or as a replacement for the
S. Green, W.A. Chambers, K.C. Gupta, R.N. Hill, P.M. Hurley, L.A. Lambert, C.C. Lee, J.K. Lee, P.T. Liu, D.K. Lowther, C.D. Roberts, V.M. Seabaugh, J.A. Springer, N.L. Wilcox   +13 more
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Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing

Alternatives to Laboratory Animals, 2019
Collagen vitrigel membranes (CVMs) comprising high-density collagen fibrils equivalent to in vivo connective tissues have been widely used in cell culture applications. A human corneal epithelium (hCE) model was previously developed by the Takezawa group, by culturing HCE-T cells (derived from hCE cells) on a CVM scaffold in a chamber that provided an ...
Hajime, Kojima, Hiroyuki, Yamaguchi, Takashi, Sozu, Nicole, Kleinstreuer, Lim, Chae-Hyung, Wannhsin, Chen, Mika, Watanabe, Takayuki, Fukuda, Kunihiko, Yamashita, Toshiaki, Takezawa   +9 more
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