Results 241 to 250 of about 7,196,791 (287)

Justification of the enucleated eye test with eyes of slaughterhouse animals as an alternative to the draize eye irritation test with rabbits

Food and Chemical Toxicology, 1993
The enucleated eye test (EET) with the isolated eye of rabbits has been recognized as a valuable alternative to the Draize test, because it represents a test system nearest to the in vivo test, without the need to use live animals. In this ex vivo bioassay, three parameters are measured to detect possible adverse eye effects, namely corneal swelling ...
M K, Prinsen, H B, Koëter
openaire   +2 more sources

Assessment of the Eye Irritating Properties of Chemicals by Applying Alternatives to the Draize Rabbit Eye Test: The Use of QSARs and In Vitro Tests for the Classification of Eye Irritation

Alternatives to Laboratory Animals, 2005
Huggins has reported on the current situation relating to the development of alternatives to the Draize eye irritation test with rabbits, and an ECVAM Working Group have reviewed the efforts needed in order to replace this animal test within the next 10 years by using the results of non-animal assessment methods.
Ingrid, Gerner, Manfred, Liebsch, Horst, Spielmann   +2 more
openaire   +2 more sources

Exfoliative cytology as a refinement of the drake eye irritancy test☆

Toxicology Letters, 1983
Collection of exfoliated cells from the eyes of albino rabbits was performed in conjunction with the Draize ocular irritancy test. At standard intervals after exposure to alcohols of known irritancy, exfoliated cells were retrieved from the conjunctival sac with a distilled water corneal rinse.
openaire   +2 more sources

Assessment of the validity of animal techniques in eye-irritation testing

Food and Chemical Toxicology, 1985
Since its introduction 40 years ago, the Draize test for eye irritancy has remained largely unchanged in spite of long-standing controversy over ethical and scientific aspects. It is suggested that deficiencies in the data derived from the test which arise from defects in the basic test design, cannot be fully compensated for by supplementary methods ...
openaire   +2 more sources

In vitro alternatives to the draize eye irritation test

Journal of Toxicology: Cutaneous and Ocular Toxicology, 1989
AbstractThe Joint Government-Industry Workshop on Progress Towards Non-Animal Alternatives to the Draize Test was organized to provide a forum for the discussion of issues involved in the regulatory acceptance of data from alternative tests and for the discussion of recent progress towards that end.
openaire   +1 more source

The status of eye irritancy testing: a regulatory perspective.

Lens and eye toxicity research, 1993
Eye irritation testing is a salient public issue and continues to escalate on the public agenda. Issues relevant to this milieu include legislative proposals to ban animal use for cosmetic testing, adequacy of the current standard (viz., the Draize Eye Irritancy Test), availability of non-animal methodologies, validation paradigm for new testing models,
openaire   +2 more sources

[In vitro alternatives to Draize eye irritation test].

Wei sheng yan jiu = Journal of hygiene research, 2006
For reasons of animal welfare and better science, a series of in vitro methods, including assays based isolated eye or cornea, Chorioallantoic membrane, cultured tissue or cell, had been established and evaluated to replace the Draize eye irritation test.
Jianchang, Zhou, Mingjie, Yang, Xingfen, Yang, Xiwen, He   +3 more
openaire   +1 more source

Eye Irritancy Testing

2014
K.P. Baran, Shayne C Gad
openaire   +1 more source

Ophthalmologic Perspectives on Eye Irritation Testing

Journal of Toxicology: Cutaneous and Ocular Toxicology, 1998
B. Nussenblatt Robert, Anthony bron, Wiley Chambers, P. McCulley James, Marc Pericoi, L. Ubels John, F. Edelhauser Henry   +6 more
openaire   +1 more source

Skin and Eye Irritation Tests on Hexanol

Journal of the American College of Toxicology, 1992
Guido A. Jacobs, Mark A. Martens
openaire   +1 more source