Results 201 to 210 of about 437,898 (254)
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A ligand's-eye view of protein similarity
Nature Methods, 2013Classification of proteins by ligand binding similarity offers an alternative approach to evolutionary methods for organizing and understanding biology, allowing new insights into protein function and physiological signal transduction.
Gerard J P, van Westen +1 more
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Fusion Proteins: Aflibercept (VEGF Trap-Eye)
2015Vascular endothelial growth factor (VEGF) inhibitors currently used to treat eye diseases have included monoclonal antibodies, antibody fragments, and an aptamer. A different method of achieving VEGF blockade in retinal diseases includes the concept of a cytokine trap.
Salman, Sarwar +7 more
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Protein carboxyl methyltransferase from cow eye lens
Biochemical and Biophysical Research Communications, 1983Protein carboxyl methyltransferase activity (S-adenosyl-L-methionine: protein carboxyl-0-methyltransferase; E.C. 2.1.1.24) has been detected in crude soluble extracts of cow eye lens. The activity incorporates methyl groups from S-adenosyl-L-methionine into endogenous lens proteins in vitro, and several of these species co-migrate electrophoretically ...
P N, McFadden, J, Horwitz, S, Clarke
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Protein and polypeptide mediated delivery to the eye
Advanced Drug Delivery Reviews, 2022Hybrid or recombinant protein-polymers, peptide-based biomaterials, and antibody-targeted therapeutics are widely explored for various ocular conditions and vision correction. They have been noted for their potential biocompatibility, potency, adaptability, and opportunities for sustained drug delivery. Unique to peptide and protein therapeutics, their
Sara Aly, Attia, J Andrew, MacKay
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Drosophila melanogaster lacks eye-pigment binding proteins
Biochemistry, 1979Drosophila melanogaster contains no detectable eye-pigment binding proteins, and the previous evidence for the presence of such protein in the cecropia moth is probably not valid. The major brown pigment of Drosophila (and of Cecropia), dihydroxanthommatin, behaves as a high molecular weight compound in Sephadex chromatography, thus leading to false ...
K, Wiley, H S, Forrest
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Eye-Lens proteins structure, superstructure, stability, genetics
Naturwissenschaften, 1994The eye lens in vertebrates and invertebrates is an avascular tissue which allows one to focus objects on the retina. The lens grows throughout life, maintaining transparency without significant turnover of its densely packed proteins. Apart from cytoskeletal and taxon-specific components, these proteins belong mainly to the alpha- and beta gamma ...
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An Eye-Opener to Protein Structures
Complexus, 2002During the last 30 years of protein research, the main emphasis has been given to crystallographic details, while the very basics of polymer statistics have largely been ignored. This has resulted in a major detail being overlooked: the closed loops of the size dictated by the polypeptide chain flexibility, of which the globular proteins are actually ...
Igor N. Berezovsky +3 more
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A ligand’s-eye view of protein binding
Journal of Computer-Aided Molecular Design, 2008Docking tools created for structure-based design and virtual screening have also been used to automate ligand alignment for comparative molecular field analysis (CoMFA). Models based on such alignments have been compared with those obtained based solely on shared ligand substructures, but such comparisons have generally failed to distinguish between ...
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Serotonin induced protein phosphorylation in the aplysia eye
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1987Serotonin (5-HT) increases the phosphorylation of two low molecular weight phosphoproteins of 23,000 and 15,000 daltons molecular weight and decreases the phosphorylation of a 20,000 dalton phosphoprotein in the isolated Aplysia eye. The cAMP analog 8-benzylthio cAMP increases and decreases the phosphorylation of the 23,000 and 20,000 dalton 5-HT ...
D P, Lotshaw, J W, Jacklet
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Proteins in tears from healthy and diseased eyes
Documenta Ophthalmologica, 1980The levels of total protein in tears from healthy donors, conjunctivitis vernalis patients, and conjunctivitis follicularis patients, were 625, 1370 and 1160 mg% respectively. Serum albumin accounted for 3.3%, 43% and 67% of the total protein of tears from these groups, and the level of proteins probably synthesized by the lacrimal gland, was in tears ...
A, Zavaro +3 more
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