Results 81 to 90 of about 13,861 (294)
Advanced Science, EarlyView.We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha +13 more
wiley +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Oftalʹmologiâ, 2019 The environmental factors influence, quite often, negatively affects the state of health. Many of them, such as smoking, deterioration in ecology, uncontrolled alcohol intake, are in detail studied in terms of harm to a human body.
V. N. Trubilin +5 more
doaj +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
Clinical Ophthalmology, 2019 Khulood Muhammad Sayed,1 Engy Mohammed Mostafa,1 Amr Mounir,1 Nesreen G Abd Elhaliem,2 Alahmady Hamad Alsmman1 1The Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt; 2The Department of Histology, Sohag Faculty of ...
Sayed KM +4 more
doaj
Multiple Eyelid Signs are Suggestive of Demodex Infestation
Clinical Ophthalmology, 2021 Lunla Udomwech, Nonthapan Phasuk School of Medicine, Walailak University, Nakhon Si Thammarat, ThailandCorrespondence: Lunla UdomwechSchool of Medicine, Walailak University, 222 Thaiburi, Tha Sala, Nakhon Si Thammarat, 80160, ThailandTel +6675 672 801Fax
Udomwech L, Phasuk N
doaj
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Hypothyroidism, eyelash loss [PDF]
Cleveland Clinic Journal of Medicine, 2020 Hiroki, Matsuura, Yu, Suganami
openaire +2 more sources
The Expanding “Cosmeceutical” Conundrum: The Growing Need for Heightened FDA Regulations in the Face of Modern Day Cosmeceuticals [PDF]
, 2012 The popularity and prevalence of cosmeceutical products is growing at an unprecedented rate both domestically and abroad. In the United States, cosmeceuticals are typically regulated as cosmetics even though these products often offer drug-like benefits.
Lee, Minsun
core
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui +9 more
wiley +1 more source