Results 161 to 170 of about 43,675 (258)

SnRNA‐seq reveals cellular heterogeneity and proliferation mechanisms in limb venous malformations

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1567-1586, August 2026.
To dissect the cellular heterogeneity and invasive mechanisms of limb venous malformations (VMs), this study first obtained tissue samples from four patients with VMs and four normal controls (NC). Single‐nucleus suspension was prepared, followed by transcriptome library construction and sequencing. After pretreatment, quality control, standardization,
Junjie Lin, Tingting Liu, Bin Fang, Xiaojuan Feng, Wenting Jiao, Changkuan Chen, Yaqing Ding, Gaozan Zhu, Wenqiu Wang, Wenbo Liu, Yuanqi Li, Shoufu Hou, Jianshe Wei, Junbo Qiao   +13 more
wiley   +1 more source

Endothelial-specific Ezh2 deficiency exacerbates blood-brain barrier dysfunction and neuroinflammation in sepsis-associated encephalopathy. [PDF]

J Neuroinflammation
Zhu H, Sun Q, Wang Y, Hu X, Pan Y, Huang T, Xu S, Mu L, Wang Y, Tong M, Tang Y, Luo Z, Yang B, Hou M, Chen Y, Chen Y, Su X, Xu X, Wang Z, Cao M, Xue C.   +20 more
europepmc   +1 more source

Patient‐Derived Organoid‐Based CRISPR Screens in Cancer Research: Applications, Advances, and Challenges

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley   +1 more source

Protocol to define the in situ proteome of endogenous PRC2 bodies in the triple-negative breast cancer cell line BoM-1833 using optoproteomics. [PDF]

STAR Protoc
Pan YC, Chang HJ, Chong WM, Liao JC, Lungu C.   +4 more
europepmc   +1 more source

RGS Family Remodeling in Breast Cancer: A Meta‐Analysis and Multi‐Omics Profiling of Prognostic Biomarkers

Cancer Medicine, Volume 15, Issue 8, August 2026.
Integrated multi‐omics analyses revealed significant dysregulation of RGS family genes in breast cancer and identified robust diagnostic and prognostic biomarkers. RGS expression was associated with genomic and epigenetic alterations, immune microenvironment features, and drug response patterns. ABSTRACT Background Breast cancer (BC) is a heterogeneous
Zohreh Mirzaei, Madiheh Mazaheri Moghaddam, Tahereh Barati, Amir Ebrahimi, Mahmoud Shekari Khaniani   +4 more
wiley   +1 more source

EZH2 and intracellular Ca²⁺ signals interdependently coordinate alloreactive and CAR-T-cell responses. [PDF]

Cell Mol Immunol
Wang Y, Huang Q, Zhou Y, Hooper R, Sanders-Braggs R, Chen M, Tian Y, Kent T, Pomerantz R, Clando G, Chung W, Issa JJ, Soboloff J, Zhang Y.   +13 more
europepmc   +1 more source

Integrated RNA Sequencing and Multi‐Bioinformatics Analyses Reveal the Molecular Mechanisms Underlying the Anti‐Breast Cancer Effects of the Fritillariae Thunbergii Bulbus–Bolbostemmatis Rhizoma Herb Pair

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Breast cancer (BC) is a highly heterogeneous malignancy with complex molecular mechanisms, highlighting the need for effective biomarkers and therapeutic targets. The Fritillariae Thunbergii Bulbus–Bolbostemmatis Rhizoma (ZBM–TBM) herb pair has been used in the treatment of BC, although its potential molecular mechanisms remain incompletely ...
Quan Tang, Dong Niu, He Li, Heng Zhou Zhu, Chun Hui Jin, Guo Qing Zhao, Xiao Dan Zhu   +6 more
wiley   +1 more source

ZRANB1 depletion inhibits neuroblastoma progression by destabilizing MYCN through EZH2-mediated deubiquitination. [PDF]

Cell Biol Toxicol
Wang Z, Cheng L, Li G, Cheng H.
europepmc   +1 more source

Epigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Osteoporosis arises from an imbalance among osteoblast‐mediated bone formation, osteoclast‐mediated bone resorption, and osteocyte‐directed mechanosensory control, but the molecular events that connect aging, hormonal change, inflammation, and mechanical unloading to bone loss remain incompletely resolved.
Minjuan Du, Leisheng Wang
wiley   +1 more source

Acute and Chronic Leukemia in Sub‐Saharan Africa: A Systematic Review

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background The four primary subgroups of leukemia include chronic myeloid leukemia (CML), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Very little is known about the regional variation of leukemia and subtypes in sub‐Saharan Africa (SSA).
Allwell A. Ayirebi, Stephen Twumasi, Linda K. Olaga, Benedict Sackey, Daniel N. M. Antonio, Richard O. Ansah, Eugene A. Ansah, John A. Sah, Enoch O. Anto, Yvonne Anang‐Quartey, Antoinette Koomson, Angela Opoku, Godfred A. Donkor, Paulina Duah, Ama G. Boadu, Samuel Essien‐Baidoo, Wina I. O. Boadu, Lilian A. Boateng   +17 more
wiley   +1 more source