Results 41 to 50 of about 43,675 (258)

Regulation and Role of EZH2 in Cancer

Cancer Research and Treatment, 2014
Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription. Enhancer of zeste homolog 2 (EZH2) is an enzymatic subunit of PRC2, and evidence shows that EZH2 plays an essential role in cancer initiation, development, progression, metastasis, and drug ...
Yamaguchi, Hirohito, Hung, Mien-Chie
openaire   +2 more sources

Aberrations of EZH2 in Cancer [PDF]

Clinical Cancer Research, 2011
Abstract Control of gene expression is exerted at a number of different levels, one of which is the accessibility of genes and their controlling elements to the transcriptional machinery. Accessibility is dictated broadly by the degree of chromatin compaction, which is influenced in part by polycomb group proteins.
Chase, Andrew, Cross, Nicholas C.
openaire   +3 more sources

circHECTD1 Promotes the Proliferation and Migration of Human Brain Vascular Smooth Muscle Cells via Interacting with KHDRBS3 to Stabilize EZH2 mRNA Expression

Journal of Inflammation Research, 2023
Meina Feng,* Wenxian Tu,* Qin Zhou, Yuanmin Du, Kang Xu, Yunfeng Wang Department of Neurology, Wuhan Brain Hospital, General Hospital of the YANGTZE River Shipping, Wuhan, People’s Republic of China*These authors contributed equally to this ...
Feng M, Tu W, Zhou Q, Du Y, Xu K, Wang Y
doaj  

EZH2 identifies the precursors of human natural killer cells with trained immunity

Cancer Biology & Medicine, 2021
Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation.
Chen Zhang, Jie Yin, Jian Zheng, Jun Xiao, Jiajian Hu, Yudong Su, Kaichen Zhou, Yingchi Zhang, Xuzhen Zhang, Hong Zhang, Qian Sun, Yang Wang, Wenwen Yu, Feng Wei, Qiang Zhao, Long Li, Xiubao Ren   +16 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Alternative splicing of EZH2 regulated by SNRPB mediates hepatocellular carcinoma progression via BMP2 signaling pathway

iScience
Summary: Increasing evidence suggests that aberrant alternative splicing plays crucial roles in tumorigenesis. However, the function of EZH2 splice variants as well as the mechanism by which EZH2 alternative splicing occurs in hepatocellular carcinoma ...
Xingyu Wang, Weiyi Liu, Chunai Zhan, Yuanyuan Zhang, Xinyu Li, Yaoyun Wang, Mengfei Sheng, Madiha Maqsood, Hang Shen, Anmin Liang, Wei Shao   +10 more
doaj   +1 more source

Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells

Epigenetics, 2021
Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumour cells is one of the major reasons for drug resistance, but ...
Anup Kumar Singh, Ayushi Verma, Akhilesh Singh, Rakesh Kumar Arya, Shrankhla Maheshwari, Priyank Chaturvedi, Mushtaq Ahmad Nengroo, Krishan Kumar Saini, Achchhe Lal Vishwakarma, Kavita Singh, Jayanta Sarkar, Dipak Datta   +11 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

EZH2 Expression and its Correlation with Clinicopathological Features in Patients with Colorectal Carcinoma

Open Life Sciences, 2016
To explore the correlation between the enhancer of zeste homolog 2 (EZH2) expression and clinicopathological features in colorectal cancer patients.
Liu Xiao-yang, Liu Hua, Gu Lin, Zheng Hai-lun   +3 more
doaj   +1 more source