Results 31 to 40 of about 248,012 (169)
Ponatinib: A Review of the History of Medicinal Chemistry behind Its Development
PharmaceuticalsThe primary treatment for chronic myeloid leukemia (CML) involves first- and second-generation tyrosine kinase inhibitors (TKIs), such as imatinib, nilotinib, bosutinib, and dasatinib.
Mayara Nascimento +11 more
doaj +1 more source
Fármacos de uso oftálmico, situación actual y nuevos fármacos en desarrollo [PDF]
, 2018 En la actualidad la prescripción de medicamentos para uso oftálmico es de gran importancia, debido alas características únicas del medio ocular.
Serrano Giménez, Pablo
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Journal of Applied Toxicology, EarlyView.ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos +4 more
wiley +1 more source
Drug Allergy with Cutaneous Manifestations. Diagnostic Approach [PDF]
, 2012 As reacções adversas a fármacos (RAF) representam um problema frequente na prática clínica. A alergia a fármacos resulta de mecanismos de hipersensibilidade imunológica e representa 6-10% do total de RAF.
Amaro, C +4 more
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Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models
Environmental Toxicology, EarlyView.ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa +9 more
wiley +1 more source
Arquivo Brasileiro de Medicina Veterinária e ZootecniaRESUMO Diversos fármacos são utilizados no tratamento da epilepsia e, assim como outros medicamentos, podem induzir a ocorrência de efeitos adversos, alguns tão graves que geram a necessidade de descontinuidade e substituição da terapia.
S.M. Caramalac +3 more
doaj +1 more source
Guía Básica de Fármacos y Dolor
Revista Electrónica de AnestesiaR, 1970 El dolor es una sensación desagradable producida bien por la exposición del organismo a estímulos nocivos capaces de producir daño tisular, o bien por lesión del sistema nervioso central.
Marta Fernández Hernández +3 more
doaj +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Retrobulbar anaesthesia (RBA) is relevant for ocular surgery in standing sedated horses. Objectives Gathering insights on experiences with RBA techniques. Study Design Cross‐sectional survey. Methods An online survey collected information on the respondents' professional background, indications, injection methods, use of ultrasound ...
Simona Lieberth +4 more
wiley +1 more source
Protocolo de manejo de complicaciones hemorrágicas en pacientes anticoagulados [PDF]
, 2014 7 páginas.Trabajo de Curso de Experto Universitario en Medicina de Urgencias y Emergencias (2013).Tutor: Francisco Temboury. Revisión retrospectiva de la literatura existente referida a la fisiopatología y tratamiento de posibles complicaciones ...
Simón Padilla, Óscar Jerónimo
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Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
The FEBS Journal, EarlyView.This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source