Results 11 to 20 of about 11,244 (122)

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates. [PDF]

Chem Biol Drug Des
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Dos Reis CRC, de Souza HVCM, Parra LC, de Souza GVCM, Zorzanelli BC, Boechat N, Hoelz LVB, Fernandes TVA.   +7 more
europepmc   +2 more sources

Symposium 12: People with type 2 diabetes treated with insulin: evidence to associate non-insulin drugs.

Revista de la Sociedad Argentina de Diabetes, 2022
Diabetes is one of the fastest growing diseases all over the world. However, the current therapeutic strategies have not been able to stop neither its progressive course nor its complications. One possible explanation might be that the diabetes diagnosis
Matías Re
doaj   +1 more source

Guía Básica de Fármacos y Dolor

Revista Electrónica de AnestesiaR, 1970
El dolor es una sensación desagradable producida bien por la exposición del organismo a estímulos nocivos capaces de producir daño tisular, o bien por lesión del sistema nervioso central.
Marta Fernández Hernández, Daniel Bouzas Pérez, Sergio Maldonado Vega, JM Carceller Malo   +3 more
doaj   +1 more source

Detección de residuos antimicrobianos en músculo, hígado y riñón de cerdo expendidos en Bogotá, Colombia

Revista U.D.C.A Actualidad & Divulgación Científica, 2016
El presente estudio, se orientó a identificar, preliminarmente, residuos de antimicrobianos en diferentes muestras de cerdo de expendios, de Bogotá, Colombia.
Sandra Ujueta Rodríguez, Alejandra Araque Marín   +1 more
doaj   +1 more source

Diagnosis of the Main Antibiotics for Broiler Chicken Recommended by Farming Centers from the Municipality of Pasto, Nariño, Colombia

Revista de Medicina Veterinaria, 2014
Objective: To determine the main antibiotics for broiler chicken, recommended by farming centers from the Municipality of Pasto, Department of Nariño, Colombia. Methods and Materials: The information was gathered through surveys with the people in charge
Juan Manuel Astaíza Martínez, Carmenza Janneth Benavides Melo, Marco Javier López Córdoba, Juan Pablo Portilla Ortiz   +3 more
doaj   +1 more source

Cafeína para o tratamento de dor

Revista Brasileira de Anestesiologia, 2012
JUSTIFICATIVA E OBJETIVOS: A cafeína é uma substância amplamente consumida com efeitos em diversos sistemas e que apresenta farmacocinética e farmacodinâmica características, causando interações com diversos medicamentos.
Cristiane Tavares, Rioko Kimiko Sakata
doaj   +1 more source

Comportamento e impacto ambiental de antibióticos usados na produção animal brasileira Performance and environmental impact of antibiotics in animal production in Brazil

Revista Brasileira de Ciência do Solo, 2010
Antibióticos têm sido utilizados em grandes quantidades nas criações animais. Muitas dessas moléculas não são totalmente metabolizadas no organismo animal e seus resíduos têm sido detectados em amostras de solo, água superficial e subterrânea.
Jussara Borges Regitano, Rafael Marques Pereira Leal   +1 more
doaj   +1 more source

Biphenyl as a Privileged Structure in Medicinal Chemistry: Advances in Anti-Infective Drug Discovery

Molecules
The discovery of novel anti-infective agents is a continuous challenge in medicinal chemistry, particularly due to the rise in resistant fungal and viral strains.
Marilia Oliva Gandi, Rodolfo Rodrigo Florido França, Frederico Silva Castelo-Branco, Nubia Boechat   +3 more
doaj   +1 more source

Sensitive and rapid titrimetric and spectrophotometric methods for the determination of stavudine in pharmaceuticals using bromate-bromide and three dyes

Anais da Academia Brasileira de Ciências, 2008
Four sensitive and rapid methods for the determination of stavudine (STV) in bulk drug and in dosage forms were developed and optimized. In titrimetry, aqueous solution of STV was treated with a known excess of bromate-bromide in HCl medium followed by ...
Kanakapura Basavaiah, Veeraiah Ramakrishna, Chikkaswamy Somashekar, Urdigere R. Anil Kumar   +3 more
doaj   +1 more source