Results 71 to 80 of about 283,616 (206)

Chemical Constituents and Biological Activities of Oxandra (Annonaceae): A Review

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Oxandra (Annonaceae) comprises 29 species distributed across South and Central America. Despite this diversity, the genus remains under‐investigated. This study presents the first comprehensive review of the chemical composition and biological activities of Oxandra species, utilizing databases such as SciFinder, ScienceDirect, PubMed, and ...
Rayssa Cota Lopes, Francisco Paiva Machado, Mateus de Freitas Brito, Thalisson Amorim de Souza, Lucas Silva Abreu   +4 more
wiley   +1 more source

Monitorización terapéutica de fármacos. Una visión general [PDF]

, 2018
La monitorización terapéutica de fármacos o MTF, es una práctica que consiste en la determinación de los valores séricos de fármaco y posterior interpretación en el contexto clínico del paciente.
García Domínguez, María Esther
core  

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, Volume 21, Issue 1, January 2026.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

Oportunidades para inovação no tratamento da leishmaniose usando o potencial das plantas e produtos naturais como fontes de novos fármacos Potential for innovation in the treatment of leishmaniasis using plants and natural products as sources of new drugs

, 2013
Leishmaniasis is considered the most neglected disease. The drugs of choice for all clinical forms of leishmaniasis are still pentavalent antimonials. Amphotericin B and pentamidine are the second line due their greater toxicity.
Luiz Filipe, G. Oliveira, B. Gilbert, G. K. V. Boas   +3 more
semanticscholar   +1 more source

A Scalable and Sustainable Synthesis of Indirubin Frameworks Enabled by Deep Eutectic Solvents

ChemSusChem, Volume 19, Issue 1, January 2026.
A sustainable protocol for the synthesis of indirubin in a choline chloride/urea deep eutectic solvent at 70°C under air affords the product in 70% yield without chromatography. The method is robust, scalable to pilot scale, and enables late‐stage functionalization, granting access to a wide range of indirubin derivatives. CHEM21 green metrics validate
Biagio Delvecchio, Luciana Cicco, Andrea Nicola Paparella, Gaetano Di Salvo, Filippo Maria Perna, Vito Capriati   +5 more
wiley   +1 more source

Perfil dos pacientes submetidos à angioplastia trasluminal coronariana com stents farmacológicos no Instituto de Cardiologia de Santa Catarina. [PDF]

, 2007
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Aquino, Vivian Wuerges de
core  

Identifying Red Flags in Myasthenia Gravis Diagnosis, Reassessment, and Myasthenic Crisis: An Italian Delphi‐Based Position Paper

Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.
Background and Purpose Myasthenia gravis (MG) is a complex autoimmune disorder affecting neuromuscular transmission, often leading to diagnostic and therapeutic challenges. Timely identification of “red flags” in diagnosis, therapeutic reassessment, and myasthenic crisis is crucial to optimizing patient outcomes. This Delphi‐based consensus is aimed at
Francesco Habetswallner, Luca Bello, Fiammetta Biasini, Bernardo Maria De Martino, Fiammetta Vanoli, Paolo E. Alboini, Giovanni Antonini, Carlo Antozzi, Valentina Damato, Vincenzo Di Stefano, Amelia Evoli, Matteo Gastaldi, Raffaele Iorio, Michelangelo Maestri, Renato Mantegazza, Roberto Massa, Rita Rinaldi, Francesco Saccà, Carmelo Rodolico, Dominic B. Fee   +19 more
wiley   +1 more source

Sensitive and rapid titrimetric and spectrophotometric methods for the determination of stavudine in pharmaceuticals using bromate-bromide and three dyes

Anais da Academia Brasileira de Ciências, 2008
Four sensitive and rapid methods for the determination of stavudine (STV) in bulk drug and in dosage forms were developed and optimized. In titrimetry, aqueous solution of STV was treated with a known excess of bromate-bromide in HCl medium followed by ...
Kanakapura Basavaiah, Veeraiah Ramakrishna, Chikkaswamy Somashekar, Urdigere R. Anil Kumar   +3 more
doaj   +1 more source

Uso de nanopartículas para la liberación de fármacos en el segmento anterior ocular: basado en nanopartículas lipídicas, dendrímeros y sistemas compuestos [PDF]

, 2019
La baja biodisponibilidad de los fármacos administrados por vía ocular para tratar las afecciones del segmento anterior del ojo, la toxicidad que pueden presentar algunos compuestos, bien por la irritabilidad que ocasionen o por los efectos secundarios ...
Montero Vílchez, Carolina
core  

Hidroxiapatita: suporte para liberação de fármacos e propriedades antimicrobianas

, 2016
Calcium phosphates are ceramic materials that have special properties such as biocompatibility and chemical similarity to bone and dental tissues of organisms.
M. V. D. Santos, J. A. Osajima, E. S. M. Filho   +2 more
semanticscholar   +1 more source