Results 81 to 90 of about 283,616 (206)

The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3 pathogenic variants

Epilepsia Open, Volume 10, Issue 6, Page 1990-1996, December 2025.
Abstract We report two cases of dual genetic diagnoses involving Lafora disease (LD) and co‐occurring neurodevelopmental disorders caused by pathogenic variants in TRIO and SHANK3, respectively. LD is an ultra‐rare, autosomal recessive, severe form of progressive myoclonus epilepsy affecting previously healthy children or adolescents. In both patients,
Lorenzo Muccioli, Francesca Bisulli, Raffaella Minardi, Maria Lucia Valentino, Micaela De Simone, Rodrigo Almeida Paroni, Edward Cesnik, Elisa Fallica, Luigi Bonan, Eleonora Pizzi, DEFEAT‐LD Study Group, Cosimo Altomare, Massimo Carella, Cinzia Costa, Giuseppe Damante, Lidia Di Vito, Giuseppe d’Orsi, Nicola Gambacorta, Paola Imbrici, Valentina Imperatore, Antonella Liantonio, Laura Licchetta, Raffaele Lodi, Paola Mantuano, Orazio Palumbo, Elena Pasini, Paolo Prontera, Luca Vignatelli, Gaetano Cantalupo, Laura Licchetta   +29 more
wiley   +1 more source

Tratamiento farmacológico de la obesidad

Revista Médica Clínica Las Condes, 2012
Para un porcentaje alto de pacientes que no logran controlar su peso solo con modificación de su hábito de alimentación y ejercicio se hace necesario contar con fármacos que apoyen los cambios de estilo de vida.
Álvarez V. Verónica, Dra.
doaj   +1 more source

Enfermería : fármacos más utilizados en urgencias hospitalarias [PDF]

, 2007
El Servicio de Urgencias del C.H.G.U.V. cuenta con una plantilla de 84 Enfermeros/as. Una parte considerable de ellos es personal de nueva incorporación, de ahí que sea prioritaria la elaboración de protocolos de actuación.
Folgado Roig, J, García Justicia, J, Loro Sancho, Natalia, Mora Palacios, R., Navarro Mira, C, Peiró Andrés, María Amparo, Sancho Sánchez, M.T, Sancho Sánchez, María José   +7 more
core   +2 more sources

Indole‐Acetic Acid Impairs Pseudomonas aeruginosa Virulence and Alters Lung Infection in Mice

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Screening for anti‐virulence activity exerted by tryptophan catabolites on laboratory and clinical strains of Pseudomonas aeruginosa showed that Indoleacetic acid (IAA) inhibits motility and pigment production, downregulates PQS gene expression, while increases oxidative stress sensitivity.
Carlos Eduardo Dias Igídio, Camila Bernardo Brito, Rafael de Oliveira Bezerra, Samantha Neves Oliveira, Cinthia Firmo Teixeira, Bárbara Maria de Amorim‐Santos, Allanis Cristiny Oliveira Andrade, Diego Lisboa Rios, Silvia Helena Sousa Pietra Pedroso, Simone Gonçalves dos Santos, Mauro Martins Teixeira, Daniele da Glória de Souza, Camila Pacheco Silveira Martins da Mata, Caio Tavares Fagundes   +13 more
wiley   +1 more source

Terapia del carcinoma de células renales [PDF]

, 2018
El cáncer renal se encuentra entre los 10 tipos de cánceres más diagnosticados a nivel mundial, representando entre el 3-5% de todos los casos diagnosticados. Una detección precoz suele estar asociada con un pronóstico favorable.
Ramírez Sánchez, Pablo
core  

Identification of D‐Fructose Dehydration Products by Infrared Multiphoton Dissociation Mass Spectrometry: The Spectral Signature of An Elusive 5‐Hydroxymethylfurfural Isomer

ChemistryOpen, Volume 14, Issue 12, December 2025.
Two distinct ionic populations coexist during triple dehydration of ammonium‐D‐fructose, arising from independent, nonintercrossing fragmentation pathways: i) low energy population, carbonyl‐protonated structure; and ii) high energy population, C2‐protonated structure, which is kinetically trapped despite thermodynamic instability.
Caterina Fraschetti, Massimiliano Aschi, Andreina Ricci, Roberta Astolfi, Antonello Filippi   +4 more
wiley   +1 more source

Stability of furosemide and aminophylline in parenteral solutions [PDF]

, 2011
Parenteral solutions (PS) are one of the most commonly used drug delivery vehicles. Interactions among the drug, components in the drug's formulation, and the PS can result in the formation of inactive complexes that limit efficacy or increase side ...
CHOLEWA, Olívia, KNIRSCH, Marcos Camargo, MAZZOLA, Priscila Gava, PENNA, Thereza Christina Vessoni, POLACWIECZ, Bronislaw, SANTOS, Carolina Alves dos   +5 more
core   +4 more sources

Predictors of Direct Oral Anticoagulant Use in Northern Italy: A Population‐Based Study

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Purpose Evidence on head‐to‐head comparison between direct oral anticoagulants (DOACs) is lacking, and the reasons for choosing one type of DOAC and switching from one DOAC to another are scarce. This study investigated the use of DOACs in an unselected population in Northern Italy during a recent period.
Luisa Ojeda‐Fernández, Greta Agostini, Anna Zanovello, Patrick Prada, Ida Fortino, Claudia Augurio, Marta Baviera   +6 more
wiley   +1 more source

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Alternativas de abordaje de la depresión en atención primaria : intervenciones farmacológicas [PDF]

, 2006
El desarrollo de fármacos antidepresivos ha avanzadonotablemente desdeelhallazgocasual, a fines de la década de los 50,deefectosantidepresivos en fármacosinicialmente investigados para otras indicaciones (iproniazida, imipramina), hasta la aparición a ...
Lou Arnal, Salvador
core   +1 more source