Results 31 to 40 of about 165,720 (231)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Rio Anime Clube: a festa dos fãs

Diálogo com a Economia Criativa, 2020
O objetivo deste artigo é analisar um evento da Indústria Cultural onde a cultura pop é celebrada: o Rio Anime Club. Foi desenvolvida uma pesquisa de “inspiração etnográfica” no Rio Anime Club realizado em maio de 2019, no clube Hebraica, no Rio de ...
Leonardo Soares da Silva, Isabel Travancas   +1 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

A cultura participativa e as práticas de letramentos de fãs de ficção: uma investigação empírica [PDF]

, 2016
Neste artigo apresento uma investigação empírica com abordagem de estudo exploratório com elementos da etnografia virtual sobre a cultura participativa e às práticas de letramentos digitais de fãs de ficção, para tanto, utilizei da observação ...
Bianca Jussara Borges Clemente, Clemente, Bianca Jussara Borges   +1 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

An Efficient Algorithm for Zeros of Bounded Generalized Ghi-Quasi-Accretive Maps

The Proceedings of the Nigerian Academy of Science, 2013
This is a research announcement of the following result. Let E be a real normed linear space in which the single-valued normalized duality map is Holder continuous on balls and let A: E → E be a bounded generalized Φ-quasi-accretive map.
C. E. Chidume FAS, C. O. Chidume
doaj   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Aplicando Durkheim a Elvis: um estudo de cultura de fãs [PDF]

, 2015
Elvis Presley, desde o início, atraiu um público de fãs e numerososfiéis ao seu estilo. Neste artigo, procuro demonstrarque não é possível transformá-lo em uma divindade.No entanto, é possível usar a teoria da religião totêmica deDurkheim para entender ...
Duffett, Mark
core   +1 more source

FÃS DE SÉRIES CANCELADAS: EVENTO FANDÔMICO E ROMPIMENTO DO PACTO FICCIONAL

Brazilian Creative Industries Journal
A longevidade de uma série de TV tem relação com a amplitude da audiência e o engajamento de seus fãs e, portanto, o cancelamento de uma série causa impacto significativo nas interações entre seus seguidores.
Clarice Greco, Fábio Levi Quintino
doaj   +1 more source