Results 51 to 60 of about 173,176 (244)

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Transmídia na teleficção brasileira: produtos e possibilidades

Comunicação & Educação, 2014
A resenha traça um panorama da obra Estratégias de transmidiação na ficção televisiva brasileira1, que se apresenta como resultado das pesquisas desenvolvidas em 2012 e 2013 pela equipe de investigadores da rede Obitel-Brasil.
Silvia Gois Dantas
doaj  

The Cumulative Incidence and Risk Factors of Recurrent Venous Thromboembolism in the Elderly

Vascular Health and Risk Management, 2020
Fahad AS Aleidan1,2 1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Anticoagulation Clinic, King Abdulaziz Medical City, Riyadh, Saudi ArabiaCorrespondence: Fahad AS AleidanCollege of Medicine, King ...
Aleidan FAS
doaj  

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Nestedness in forest mammals is dependent on area but not on matrix type and sample size: an analysis on different fragmented landscapes

Brazilian Journal of Biology
Nestedness, the pattern in which the species of a species-poor community are a subset of species-rich communities, can provide information regarding species order of extinction, which is vital knowledge for conservation biology.
JFS. Menezes, FAS. Fernandez
doaj   +1 more source

A influência do Facebook nas vendas : a perceção dos consumidores de moda [PDF]

, 2012
Um dos fenómenos sociais atualmente mais em foco, e que tem vindo a crescer de forma intensa, são as redes sociais materializadas na Internet. Surgiram como meio de fomentar o contacto entre pessoas conhecidas, no entanto, têm vindo a crescer como forma ...
Brito, Miguel António Sousa Abrunhosa de, Carvalho, Helder, Mendes, Eliana   +2 more
core  

Culturas de resistência e média alternativos: os fanzines punk portugueses [PDF]

, 2015
Embora a produção de fanzines anteceda o surgimento do punk, a verdade é que foi com ele que os fanzines se tornaram relevantes enquanto espaços de liberdade de pensamento e criação, bem como enquanto alternativa aos meios de comunicação convencionais ...
Guerra, Paula, Quintela, Pedro
core   +2 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts. [PDF]

PLoS ONE, 2009
Avicins, a family of triterpene electrophiles originally identified as potent inhibitors of tumor cell growth, have been shown to be pleiotropic compounds that also possess antioxidant, anti-mutagenic, and anti-inflammatory activities.
Zhi-Xiang Xu, Tian Ding, Valsala Haridas, Fiona Connolly, Jordan U Gutterman   +4 more
doaj   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source