Results 121 to 130 of about 170,875 (244)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Challenging the myth: comparing early complications of native and periprosthetic distal femur fractures. The role of implant stability. [PDF]

Arch Orthop Trauma Surg
Lampert C, Faust L, Beckers G, Cavalcanti Kußmaul A, Holzapfel BM, Böcker W, Neuerburg C, Pachmann F.   +7 more
europepmc   +1 more source

Comparação epidemiológica entre as fraturas de fêmur proximal atendidas em um hospital secundário e um terciário = Epidemiological comparison between proximal femur fractures in a secondary and a tertiary hospital

, 2021
Weby Delsin Mizael
openalex   +1 more source

Efeitos sítio-ósseo dependentes no fêmur e vértebra de ratas com disfunções tireoidianas [PDF]

, 2010
Jankerle Neves Boeloni, Juneo Freitas Silva, Flávia do Carmo Magalhães, Alfredo M. Góes, Rogéria Serákides   +4 more
openalex   +1 more source

FRATURAS DE FÊMUR EM IDOSOS: COMPARAÇÃO CLÍNICO-EPIDEMIOLÓGICA EM CASCAVEL, PARANÁ, DE 2012 A 2022

, 2023
Rodrigo Bortolini, E Schmitt
openalex   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Augmented Reality-Based Femur Registration With Head-Mounted Display and Infrared Tracking Device as Stand-Alone Navigation Tool: A Preclinical Validation Study. [PDF]

Health Sci Rep
Himpe N, Neuville Q, Frantz T, Vandemeulebroucke J, Moke L, Vles G, Ghijselings S, Scheerlinck T.   +7 more
europepmc   +1 more source

Avaliação funcional do joelho após síntese de fraturas diafisárias do fêmur com haste intramedular retrógrada

, 2023
Célio Gomes Da Silva Neto, Vinicius Ferreira Pires Bueno, Gabriel Fonseca de Oliveira Costa, Diego Wagmacker Nascimento   +3 more
openalex   +2 more sources

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source