Results 111 to 120 of about 179,884 (241)

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Morbimortalidade em idosos por fratura proximal do fêmur

Texto & Contexto Enfermagem, 2009
El aumento del número de ancianos es una realidad en nuestro país, lo que ha producido un debate acerca de los hechos que producen discapacidad en esta franja etaria, destacándose la ocurrencia de caídas, por sus consecuencias físicas, psicológicas y ...
Gerardo Vasconcelos Mesquita, Myrna Amélia Lobão Teixeira de Abreu Lima, Ana Maria Ribeiro dos Santos, Eucário Leite Monteiro Alves, José Nazareno Pearce de Oliveira Brito, Maria do Carmo de Carvalho e Martins   +5 more
doaj  

Tendência temporal de internação por fratura de fêmur em idosos no Brasil de 2008 à 2018

, 2020
Objetivo: Analisar a tendência temporal de internação por fratura de fêmur em idosos no Brasil de 2008 a 2018. Método: Estudo ecológico de séries temporais de internação por fratura de fêmur em idosos no Brasil. Dados do Sistema de Informação Hospitalar,
Bressan, Matheus
core  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Lag Vidasının Farklı Sabitleme Pozisyonunda, Dinamik Kalça Çivisi ile Tedavi Edilen İntertrokanterik Femoral Kırıklarının Kararlılığı

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2014
Bu çalışmada, Dinamik Kalça Çivisinin (DKÇ) sabitlenmesinde lag vidasının farklı konumlarına göre intertrokanterik femur kırıklarının kararlılığı analitik olarak incelenmektedir. Bilgisayarlı tomografi görüntüleri kullanılarak oluşturulan insan femurunun
Talip ÇELİK, İbrahim MUTLU, Arif ÖZKAN, Yasin KİŞİOĞLU   +3 more
doaj  

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Evolução temporal da ocorrência de fratura proximal do fêmur em idosos no Brasil

, 2018
As fraturas do terço proximal do fêmur são um evento relativamente frequente e têm consequências graves quando ocorre em idosos. O objetivo da pesquisa foi analisar a tendência temporal da incidência de 330.250 fraturas do fêmur proximal e as taxas de ...
Schuroff, Gustavo Zeni
core  

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

FRATURA DE FÊMUR: UMA REVISÃO SISTEMÁTICA DE LITERATURA

Introdução: Este trabalho aborda o aumento do número de fraturas de fêmur durante os anos de pandemia de COVID-19, que foi um período que impactou profundamente a saúde pública em diversas esferas.
Torres, Márcio, Bessa, Alexandre, Pinheiro Cintra, Leandro   +2 more
core  

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source