Results 121 to 130 of about 186,247 (244)

Morbimortalidade em idosos por fratura proximal do fêmur

open access: yesTexto & Contexto Enfermagem, 2009
El aumento del número de ancianos es una realidad en nuestro país, lo que ha producido un debate acerca de los hechos que producen discapacidad en esta franja etaria, destacándose la ocurrencia de caídas, por sus consecuencias físicas, psicológicas y ...
Gerardo Vasconcelos Mesquita   +5 more
doaj  

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao   +12 more
wiley   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

open access: yesAdvanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song   +12 more
wiley   +1 more source

Miss-a-nail Technique of Femur Neck Fracture with Femur Interlocking Nail in Situ: A Technical Description

open access: yesJournal of Orthopaedic Case Reports
Introduction: The neck of the femur fracture is more prevalent in the elderly, but can occur in young individuals due to high-energy trauma. Management of neck femur fracture with the femur interlocking nail in situ is a technically demanding case.
Nischay Kaushik   +5 more
doaj   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

open access: yesAdvanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang   +12 more
wiley   +1 more source

Health condition of hospitalized elderly with fêmur fracture

open access: yesO Mundo da Saúde, 2016
The health status of the elderly is a determinant that can enable them to enjoy growing old with a preserved quality of life. The objective of this study was to gain an understanding into the health conditions of the elderly before they are ...
Letícia Pilotto Casagranda   +5 more
doaj  

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

open access: yesAdvanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan   +12 more
wiley   +1 more source

Mechanical study in vitro of the resistance of axial forces of 3.5 mm cannulated and conventional screws in head and femoral neck fractures [PDF]

open access: yes
Background: Proximal femoral fractures account for 25% of all femoral fractures in dogs and are more common in young animals. Osteosynthesis of femoral head and neck fractures is a complex procedure that can be performed using conventional screws or ...
Baccarin, Daniel Castelo Branco   +3 more
core  

3D Large‐Scale Subwavelength‐Resolution Sound Sheet Tomography Based on an Active and Programmable Circular Meta‐Array

open access: yesAdvanced Science, EarlyView.
A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang   +11 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy