Results 101 to 110 of about 179,884 (241)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Fratura de fêmur em idosos: relato de experiência

Objetivo: Analisar a incidência e as características das fraturas de fêmur em pacientes idosos, destacando sua relevância como problema de saúde pública.
Diniz, Mariana de Faria Gardingo, Leandro, Paula Costa, Nunes, Tales Corrêa, Soares, Vitor de Souza   +3 more
core  

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

DESAFIOS ASSOCIADOS À FRATURA DE FÊMUR EM IDOSOS

A fratura de fêmur em idosos é uma condição clínica de grande relevância, visto que representa um problema de saúde significativo para a população idosa.
Ribeiro, Ana Clara, Gustavo Prado Faleiros Valente, Espinosa Ribeiro de Oliveira, Amanda   +2 more
core  

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Miss-a-nail Technique of Femur Neck Fracture with Femur Interlocking Nail in Situ: A Technical Description

Journal of Orthopaedic Case Reports
Introduction: The neck of the femur fracture is more prevalent in the elderly, but can occur in young individuals due to high-energy trauma. Management of neck femur fracture with the femur interlocking nail in situ is a technically demanding case.
Nischay Kaushik, Ambrish Kumar Singh, Salman Durrani, Pramod Kumar, Vedant Bajaj, Jashandeep Singh   +5 more
doaj   +1 more source

Estudo radiográfico dos aspectos anatômicos do fêmur proximal dos adultos brasileiros

, 2015
ResumoObjetivoVerificar a geometria do fêmur da população brasileira por meio de estudo radiográfico e correlacionar os valores quanto ao sexo e ao lado direito/esquerdo.MétodosForam analisadas 500 radiografias anteroposteriores de bacia de pacientes ...
de Souza, Eduardo Soares, Fernando Abdala, Abdala, Fernando, Tércio Henrique Soares de Farias, Natália Miki, Borges, Vinícius Quadros, Miki, Natália, Eduardo Soares de Souza, de Farias, Tércio Henrique Soares, Vinícius Quadros Borges   +9 more
core   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

PANORAMA EPIDEMIOLÓGICO DE PACIENTES COM FRATURA DE FÊMUR NO BRASIL: UM ESTUDO RETROSPECTIVO

A fratura de fêmur representa um relevante problema de saúde pública, especialmente entre idosos, estando associada a elevada morbimortalidade e a significativo impacto econômico para os sistemas de saúde.
Reis , Nayra, Silva, Lhais Santos da
core   +1 more source

Incidência e caracterização de idosos na clínica ortopédica do Hospital Regional Cáceres por fratura de fêmur.

, 2013
A população idosa vem crescendo gradativamente nos últimos anos, com isso aumenta a incidência de idosos com risco de sofrer uma queda e desenvolver uma fratura. A fratura de fêmur constitui causa significante de perda funcional e incapacidade. Objetivo:
Danyella Rodrigues De Almeida, Wilton Nelson Lançoni De Campos, Renata Tomazelli, Deise Ferreira Romão, Franciely Maria Carrijo Campos, Andréia Costa Ferreira Ferreira   +5 more
core   +1 more source