Results 101 to 110 of about 187,949 (228)

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Morbimortalidade em idosos por fratura proximal do fêmur

Texto & Contexto Enfermagem, 2009
El aumento del número de ancianos es una realidad en nuestro país, lo que ha producido un debate acerca de los hechos que producen discapacidad en esta franja etaria, destacándose la ocurrencia de caídas, por sus consecuencias físicas, psicológicas y ...
Gerardo Vasconcelos Mesquita, Myrna Amélia Lobão Teixeira de Abreu Lima, Ana Maria Ribeiro dos Santos, Eucário Leite Monteiro Alves, José Nazareno Pearce de Oliveira Brito, Maria do Carmo de Carvalho e Martins   +5 more
doaj  

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Health condition of hospitalized elderly with fêmur fracture

O Mundo da Saúde, 2016
The health status of the elderly is a determinant that can enable them to enjoy growing old with a preserved quality of life. The objective of this study was to gain an understanding into the health conditions of the elderly before they are ...
Letícia Pilotto Casagranda, Fernanda dos Santos, Celmira Lange, Patrícia Mirapalheta Pereira de Llano, Viviane Martin Milbrath, Andressa Hoffmann Pinto   +5 more
doaj  

Miss-a-nail Technique of Femur Neck Fracture with Femur Interlocking Nail in Situ: A Technical Description

Journal of Orthopaedic Case Reports
Introduction: The neck of the femur fracture is more prevalent in the elderly, but can occur in young individuals due to high-energy trauma. Management of neck femur fracture with the femur interlocking nail in situ is a technically demanding case.
Nischay Kaushik, Ambrish Kumar Singh, Salman Durrani, Pramod Kumar, Vedant Bajaj, Jashandeep Singh   +5 more
doaj   +1 more source

Latent Diffusion Process With Mechanistic Guidance For Designing Functionally Graded Metamaterials With Perfect Connectivity

Advanced Science, EarlyView.
A latent diffusion‐based framework is proposed for designing functionally graded metamaterials with perfect connectivity. By integrating vector‐quantized latent representations with mechanistic guidance, the framework enables accurate inverse design toward target elastic properties.
Jongbin Yu, Dosung Lee, Namjung Kim
wiley   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

PANORAMA EPIDEMIOLÓGICO DE PACIENTES COM FRATURA DE FÊMUR NO BRASIL: UM ESTUDO RETROSPECTIVO [PDF]

A fratura de fêmur representa um relevante problema de saúde pública, especialmente entre idosos, estando associada a elevada morbimortalidade e a significativo impacto econômico para os sistemas de saúde.
Reis , Nayra, Silva, Lhais Santos da
core   +1 more source

Lag Vidasının Farklı Sabitleme Pozisyonunda, Dinamik Kalça Çivisi ile Tedavi Edilen İntertrokanterik Femoral Kırıklarının Kararlılığı

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2014
Bu çalışmada, Dinamik Kalça Çivisinin (DKÇ) sabitlenmesinde lag vidasının farklı konumlarına göre intertrokanterik femur kırıklarının kararlılığı analitik olarak incelenmektedir. Bilgisayarlı tomografi görüntüleri kullanılarak oluşturulan insan femurunun
Talip ÇELİK, İbrahim MUTLU, Arif ÖZKAN, Yasin KİŞİOĞLU   +3 more
doaj