Results 101 to 110 of about 186,247 (244)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Single-stage bilateral distal femur replacement for traumatic distal femur fractures

Arthroplasty Today, 2019
Treatment of periprosthetic distal femur fractures and comminuted intraarticular distal femur fractures with previous arthritis remains a difficult challenge for orthopedic surgeons. Previous case series have shown that distal femur replacement (DFR) can
David C. Neal, MD, Varun Sambhariya, MD, Apollo Tran, BS, Shawn K. Rahman, BSA, Thad J. Dean, DO, Russel A. Wagner, MD, Hugo B. Sanchez, MD, PhD   +6 more
doaj   +1 more source

Associação do marcador molecular LEPR1 A>G com características de integridade óssea em frangos de corte. [PDF]

, 2012
Projeto/Plano de Ação: 02.10.06 ...
FORNARI, M. B., LEDUR, M. C., MARCHESI, J. A. P., NEIS, K. L., PEIXOTO, J. de O., TESSMANN, A. L.   +5 more
core  

Is structural and mild leg length discrepancy enough to cause a kinetic change in runners' gait? [PDF]

, 2008
Desigualdade de membros inferiores (DMI) está presente em cerca de 70% da população geral, podendo ser do tipo estrutural onde existe diferença no comprimento de estruturas ósseas, ou funcional, como resultado de alterações mecânicas dos membros ...
PEREIRA, Carla Sonsino, SACCO, Isabel de Camargo Neves   +1 more
core   +2 more sources

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Levantamento preliminar de pulgões no Estado do Amapá. [PDF]

, 2017
Considerando a importância dos afídeos como pragas, são necessários estudos regionalizados em todas as áreas de produção agrícola do país. Este trabalho foi realizado com o objetivo de contribuir para o conhecimento das espécies de afídeos, que ocorrem ...
JORDÃO, A. L., MICHELOTTO, M. D., SILVA, R. A. da   +2 more
core  

Postural assessment by photogrammetry in patients with idiopathic scoliosis undergoing arthrodesis [PDF]

, 2012
INTRODUCTION: Scoliosis is a structural change of the vertebrae three-dimensiona. Quantification of lateral deviation after surgical correction could assist about the prognosis for the evolution of curvature and better direction in rehabilitation ...
Crescentini, Milena Carlos Vidotto, Gotfryd, Alberto Ofenhejm, Poletto, Patrícia Rios, Santos, Lucas De Macedo Dos, Souza, Tayla Perosso De, Yi, Liu Chiao   +5 more
core   +2 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Lag Vidasının Farklı Sabitleme Pozisyonunda, Dinamik Kalça Çivisi ile Tedavi Edilen İntertrokanterik Femoral Kırıklarının Kararlılığı

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2013
Bu çalışmada, Dinamik Kalça Çivisinin (DKÇ) sabitlenmesinde lag vidasının farklı konumlarına göre intertrokanterik femur kırıklarının kararlılığı analitik olarak incelenmektedir. Bilgisayarlı tomografi görüntüleri kullanılarak oluşturulan insan femurunun
Arif Özkan, İbrahim Mutlu, Talip Çelik, Yasin Kişioğlu   +3 more
doaj   +4 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source