Results 91 to 100 of about 179,884 (241)

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

open access: yesAdvanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan   +12 more
wiley   +1 more source

Radiological assessment of the femoral bowing in Japanese population

open access: yesSICOT-J, 2016
Introduction: Differences in the magnitude of bowing between races are well-known characteristics of the femur. Asian races have an increased magnitude of femoral bowing but most of the orthopedic implants designed for the femur do not match this ...
Abdelaal Ahmed Hamed Kassem   +8 more
doaj   +1 more source

3D Large‐Scale Subwavelength‐Resolution Sound Sheet Tomography Based on an Active and Programmable Circular Meta‐Array

open access: yesAdvanced Science, EarlyView.
A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang   +11 more
wiley   +1 more source

Perfil funcional, sociodemográfico e epidemiológico de idosos hospitalizados por fratura proximal de fêmur

open access: yesKairós Gerontologia, 2015
A fratura proximal de fêmur (FPF) está relacionada a altos índices de morbidade e a grande impacto sobre a capacidade funcional do idoso. O objetivo do estudo foi traçar o perfil funcional de pacientes idosos hospitalizados por FPF, analisando os tipos ...
Danielle Ferreira Santana   +3 more
doaj  

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

open access: yesAdvanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng   +15 more
wiley   +1 more source

A cirurgia precoce nas fraturas do fêmur proximal em idosos reduz a taxa de mortalidade?

open access: yes, 2019
Resumo Objetivo Analisar se a redução no tempo de espera para cirurgia ortopédica nos pacientes idosos com fratura da extremidade proximal do fêmur impacta na redução da mortalidade intra-hospitalar, da mortalidade em 6 meses de seguimento, e ...
Guilherme Boni   +5 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

open access: yesAdvanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi   +7 more
wiley   +1 more source

Efeitos do treinamento em natação sobre propriedades mecânicas e estruturais do fêmur de ratas ovariectomizadas

open access: yes, 2014
Investigamos os efeitos do treinamento em natação (TN) sobre propriedades mecânicas e estruturais do fêmur de ratas ovariectomizadas. Ratas Wistar com peso corporal (PC) de 271,42 ± 17,6 g e 20 semanas de idade foram submetidas à ovariectomia (OVX) ou ...
Del Carlo, Ricardo Junqueira   +9 more
core  

Análise de resultados da osteotomia extensora percutânea de fêmur distal em pacientes com amioplasia

open access: yes, 2014
ResumoObjetivorevisar os prontuários de 19 pacientes com diagnóstico de amioplasia, submetidos à osteotomia extensora percutânea de fêmur distal, para correção de deformidade fixa em flexão dos joelhos.Métodosanalisamos 37 osteotomias em 35 joelhos com ...
Moreira, Marcus Vinicius   +2 more
core   +1 more source

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