Results 91 to 100 of about 187,949 (228)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Perfil funcional, sociodemográfico e epidemiológico de idosos hospitalizados por fratura proximal de fêmur

Kairós Gerontologia, 2015
A fratura proximal de fêmur (FPF) está relacionada a altos índices de morbidade e a grande impacto sobre a capacidade funcional do idoso. O objetivo do estudo foi traçar o perfil funcional de pacientes idosos hospitalizados por FPF, analisando os tipos ...
Danielle Ferreira Santana, Helena França Correia dos Reis, Diego Jorge Souza Ezequiel, Daniel Dominguez Ferraz   +3 more
doaj  

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Emprego da colocefalectomia para tratamento de necrose asséptica da cabeça do fêmur em dálmata [PDF]

A necrose asséptica da cabeça do fêmur, também conhecida como doença de Legg Calvé-Perthes, é uma afecção que acomete, majoritariamente, cães de raças pequenas.
Reis, Marcus Vinícius Lacerda, Passini, Mateus, Florêncio, Jacqueline Verônica Almeida Afonso, Moreira, Felipe Francisco, Albertoni, Luís Gustavo da Silva, Gueiros Filho, Edvaldo, Costa, Juliana Imbroisi Cunha da   +6 more
core   +1 more source

Radiological assessment of the femoral bowing in Japanese population

SICOT-J, 2016
Introduction: Differences in the magnitude of bowing between races are well-known characteristics of the femur. Asian races have an increased magnitude of femoral bowing but most of the orthopedic implants designed for the femur do not match this ...
Abdelaal Ahmed Hamed Kassem, Yamamoto Norio, Hayashi Katsuhiro, Takeuchi Akihiko, Morsy Ahmad Fawaz, Miwa Shinji, Kajino Yoshitomo, Rubio Donnel A., Tsuchiya Hiroyuki   +8 more
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Migração intrapélvica do parafuso cefálico da haste intramedular longa para fêmur proximal: Relato de caso*

, 2019
ResumoO uso dos dispositivos cefalomedulares tem ganhado popularidade no tratamento das fraturas do fêmur proximal. Apesar das vantagens biomecânicas, várias complicações são descritas, entre as quais a migração medial do parafuso cefálico é pouco ...
Saulo Gomes de Oliveira, Fernando Junqueira de Faria, Elton Luiz Batista Cavalcante, Rubens Azevedo Rodrigues, José Eduardo Grandi Ribeiro Filho, Nelson Elias   +5 more
core   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source