Results 181 to 190 of about 83,861 (315)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

From Microstates to Macrostates in the Conformational Dynamics of GroEL: A Single-Molecule Förster Resonance Energy Transfer Study. [PDF]

J Phys Chem Lett, 2023
Liebermann DG, Jungwirth J, Riven I, Barak Y, Levy D, Horovitz A, Haran G.   +6 more
europepmc   +1 more source

A Time‐Resolved Förster Resonance Energy Transfer Platform for the Facile Quantification of Small Molecule Drugs in Cell Lysate [PDF]

Ralph Mazitschek, Ralph Mazitschek
openalex   +1 more source

Experimental determination of the bioluminescence resonance energy transfer (BRET) Förster distances of NanoBRET and red-shifted BRET pairs

, 2020
Felix Weihs, Jian Wang, Kevin D. G. Pfleger, Helen Dacres   +3 more
openalex   +1 more source

Correlating Calcium Binding, Förster Resonance Energy Transfer, and Conformational Change in the Biosensor TN-XXL [PDF]

, 2012
Anselm Geiger, L. Russo, Thomas Gensch, Thomas Thestrup, Stefan Becker, Karl‐Peter Hopfner, Christian Griesinger, Gregor Witte, Oliver Griesbeck   +8 more
openalex   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Accurate and Convenient Lung Cancer Diagnosis through Detection of Extracellular Vesicle Membrane Proteins via Förster Resonance Energy Transfer. [PDF]

Nano Lett, 2023
Xiao S, Yao Y, Liao S, Xu B, Li X, Zhang Y, Zhang L, Chen Q, Tang H, Song Q, Dong M.   +10 more
europepmc   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Förster resonance energy transfer efficiency measurements on vinculin tension sensors at focal adhesions using a simple and cost-effective setup. [PDF]

J Biomed Opt, 2023
Dubois C, Houel-Renault L, Erard M, Boustany NN, Westbrook N.   +4 more
europepmc   +1 more source

Circularly Polarized Luminescent Liquid Crystal Copolymers Constructed by Triplet–Singlet Förster‐Resonance Energy Transfer: Achieving Large G_lum Values, Long Lifetime, and High Photoluminescence Quantum Yield [PDF]

Mengdie Zhou, Peng Lü, Zhipeng Xu, Yuyi Wang, Yongjie Yuan, Yongyang Gong, Hailiang Zhang   +6 more
openalex   +1 more source