Results 41 to 50 of about 6,815,038 (214)

Synchronized Ablation of Multifocal Tumors Enabled by Multi‐Channel Lanthanide Nanocomposites

Advanced Materials, EarlyView.
A multi‐channel lanthanide nanocomposite enables orthogonal monitoring of tumor pH, glutathione, and temperature to guide customized therapy. Real‐time luminescence readouts determine a single irradiation protocol that synchronizes drug release and photothermal treatment, allowing efficient ablation of multifocal tumors while minimizing overtreatment ...
Fang Li, Zheng Wei, Francesco G. Mutti, Hong Zhang, Felix F. Loeffler, Yuxin Liu, Xingjun Zhu   +6 more
wiley   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Der Nach Engelland reisende Curieuse Passagier, Oder Kurtze Beschreibung Der Stadt London und derer umliegenden Oerter, Denenjenigen, so dahin zu reisen gedencken / Zum besten ans Licht gegeben von J. B. Küchelbeckern

Vorlageform des Erscheinungsvermerks: Hanover, Zu finden bey Nicolaus Förster und Sohn, 1726.Ill. (Holzschn.
Küchelbecker, Johann Basilius
core   +1 more source

Mechanochemical Activation of a Bridged‐Exciplex Optical Force Probe

Advanced Science, EarlyView.
A bridged‐exciplex optical force probe is synthesized, switching from solvatochromic charge‐transfer emission in the latent state to intense locally excited emission upon activation. This dual photophysical response with additional changes in quantum yield and fluorescence lifetime enables precise environmental sensing and distinct optical readouts ...
Ronja Schumann, Andreas Bock, Felix Majer, Michael Baumann, Michael Olney‐Fraser, Lev Kazak, Fedor Jelezko, Alexander J. C. Kuehne, Robert Göstl   +8 more
wiley   +1 more source

Homeotropic alignment and Förster resonance energy transfer: the way to a brighter luminescent solar concentrator [PDF]

, 2014
We investigate homeotropically aligned fluorophores and Förster resonance energy transfer (FRET) for luminescent solar concentrators using Monte-Carlo ray tracing.
Kenyon, AJ, Papakonstantinou, I, Clemens Tummeltshammer, Ioannis Papakonstantinou, Alaric Taylor, Tummeltshammer, C, Anthony J. Kenyon, Taylor, A   +7 more
core   +1 more source

Förster Resonance Energy Transfer Measurements in Living Plant Cells

, 2021
Schmidtpott S, Seidel T. Förster Resonance Energy Transfer Measurements in Living Plant Cells. Journal of visualized experiments : JoVE. 2021;(172).Sensitized emission-based Forster resonance energy transfer (FRET) experiments are easily done but depend ...
Schmidtpott, Sonja, Seidel, Thorsten, Thorsten Seidel, Sonja Michèle Schmidtpott   +3 more
core   +1 more source

Responsive Membrane Antenna Enables Adaptive Biohybrid Interface for Photosynthesis Promotion, Stress Reporting and Modulation

Advanced Science, EarlyView.
An environmentally responsive antenna assembled onto the algal cell membrane creates a biohybrid with a responsive interface that promotes photosynthesis under normal conditions and shifts to H2O2‐triggered stress reporting and modulation upon stress onset, boosting environmental sensing and adaptive response.
Bing Liu, Gongmeiyue Su, Jingyi Shi, Hang Yao, Yuchun Han, Zhao Li, Chengcheng Zhou   +6 more
wiley   +1 more source

Getreuer Hofmeister auf Academien und Reisen ...

Auch als Sekundärausg.
Tschirnhaus, Ehrenfried Walther
core   +2 more sources

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source