Results 121 to 130 of about 25,145 (258)

Higher-dimensional Willmore energy as holographic entanglement entropy

Journal of High Energy Physics
The vacuum entanglement entropy of a general conformal field theory (CFT) in d = 5 spacetime dimensions contains a universal term, F(A), which has a complicated and non-local dependence on the geometric details of the region A and the theory. Analogously
Giorgos Anastasiou, Ignacio J. Araya, Pablo Bueno, Javier Moreno, Rodrigo Olea, Alejandro Vilar Lopez   +5 more
doaj   +1 more source

Stochastic Neighbor Embedding under f-divergences

, 2018
The t-distributed Stochastic Neighbor Embedding (t-SNE) is a powerful and popular method for visualizing high-dimensional data. It minimizes the Kullback-Leibler (KL) divergence between the original and embedded data distributions. In this work, we propose extending this method to other f-divergences.
Im, Daniel Jiwoong, Verma, Nakul, Branson, Kristin   +2 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Molecular and Morphological Characterization of Fasciola spp. Isolated from Different Host Species in a Newly Emerging Focus of Human Fascioliasis in Iran

Veterinary Medicine International, 2014
The current study aimed to find out the morphometric and genotypic divergences of the flukes isolated from different hosts in a newly emerging focus of human fascioliasis in Iran. Adult Fasciola spp.
Reza Shafiei, Bahador Sarkari, Seyed Mahmuod Sadjjadi, Gholam Reza Mowlavi, Abdolali Moshfe   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Corrected calculation for the non-local solution to the g − 2 anomaly and novel results in non-local QED

Journal of High Energy Physics
We provide the corrected calculation of the (g − 2) μ in non-local QED previously done in the literature. In specific, we show the proper technique for calculating loops in non-local QED and use it to find the form factors F 1(q 2) and F 2(q 2) in non ...
Fayez Abu-Ajamieh, Nobuchika Okada, Sudhir K. Vempati   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In silico analysis of amino acid variation in human respiratory syncytial virus: insights into immunodiagnostics

Memorias do Instituto Oswaldo Cruz
BACKGROUND The highly contagious nature of human respiratory syncytial virus (HRSV) and the gravity of its infection in newborns and vulnerable adults pose a serious public health problem.
Claudemir Souza, Nilson IT Zanchin, Marco A Krieger, Adriana Ludwig   +3 more
doaj   +1 more source

Multivariate f-Divergence Estimation With Confidence

, 2014
The problem of f-divergence estimation is important in the fields of machine learning, information theory, and statistics. While several nonparametric divergence estimators exist, relatively few have known convergence properties. In particular, even for those estimators whose MSE convergence rates are known, the asymptotic distributions are unknown. We
Moon, Kevin R., Hero III, Alfred O.
openaire   +2 more sources