Results 101 to 110 of about 9,955,680 (232)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A General Divergence Measure for Monotonic Functions and Applications in Information Theory [PDF]

, 2004
A general divergence measure for monotonic functions is introduced. Its connections with the f−divergence for convex functions are explored.
Dragomir, Sever S
core   +1 more source

In silico analysis of amino acid variation in human respiratory syncytial virus: insights into immunodiagnostics

Memorias do Instituto Oswaldo Cruz
BACKGROUND The highly contagious nature of human respiratory syncytial virus (HRSV) and the gravity of its infection in newborns and vulnerable adults pose a serious public health problem.
Claudemir Souza, Nilson IT Zanchin, Marco A Krieger, Adriana Ludwig   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Comparative genomic analyses provide new insights into phylogenetic and functional diversification in genus Fenollaria

Frontiers in Microbiology
The genus Fenollaria has gained attention due to its associations with human prostate cancer, colorectal cancer and other diseases. The higher abundance of Fenollaria was believed to be associated with biochemical recurrence of prostate cancer but ...
Shaojing Wang, Shaojing Wang, Lijuan Kang, Lijuan Kang, Mei Li, Mei Li, Xiaodong Zhou, Xiaodong Zhou, Bowen Li, Bowen Li, Fei Wang, Fei Wang, Jinhuan Meng, Jinhuan Meng, Changying Li, Changying Li, Kuo Yang, Kuo Yang   +17 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

One-loop QCD corrections to SSA in unweighted Drell-Yan processes

Journal of High Energy Physics
We study one-loop QCD corrections to the single transverse spin asymmetry in Drell-Yan process. The invariant mass of virtual photon and angular distributions of final lepton in Collins-Soper frame are measured.
Guang-Peng Zhang
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Hidden zeros for higher-derivative YM and GR amplitudes at tree-level

Journal of High Energy Physics
We extend the recently discovered phenomenon of hidden zeros to tree amplitudes for Yang-Mills (YM) and general relativity (GR) theories with higher-derivative interactions. This includes gluon amplitudes with a single insertion of the local F 3 operator,
Kang Zhou
doaj   +1 more source