Results 171 to 180 of about 15,544,554 (381)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Proceedings of Proceedings of the Corfu Summer Institute 2014 — PoS(CORFU2014), 2015 In this lecture, an overview of current F-theory model building techniques is presented. In F-theory GUT symmetries are associated to the singularities of the elliptically fibred internal (compact) space. Models with gauge groups emerging as subgroups of the exceptional group E8 are presented. Moreover, GUTs with abelian and discrete symmetries arising
openaire +2 more sources
When rational sections become cyclic — Gauge enhancement in F-theory via Mordell-Weil torsion
Journal of High Energy Physics, 2018 We explore novel gauge enhancements from abelian to non-simply-connected gauge groups in F-theory. To this end we consider complex structure deformations of elliptic fibrations with a Mordell-Weil group of rank one and identify the conditions under which
Florent Baume +3 more
doaj +1 more source
Discussion: “A Study of the Theory of Axial-Flow Pumps” (Wislicenus, G. F., 1945, Trans. ASME, 67, pp. 451–463) [PDF]
, 1945 A. J. Stepanoff
openalex +3 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
, 2020 We propose 4-point S-matrices for three-dimensional F-theory. We will use the twistor formalism to facilitate constructing the amplitude. We write the amplitude in a way such that the F-symmetry (U-duality symmetry) is manifest. The amplitude can be schematically written as $A_{4} = w^{4}/stu$, where $w$ is an analog of the linearized Weyl tensor in F ...
Siegel, Warren, Wang, Yu-Ping
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Model Building with F-Theory [PDF]
arXiv, 2008 Despite much recent progress in model building with D-branes, it has been problematic to find a completely convincing explanation of gauge coupling unification. We extend the class of models by considering F-theory compactifications, which may incorporate unification more naturally.
arxiv
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source