Results 161 to 170 of about 16,257,561 (327)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Twisted Fibrations in M/F-theory

Journal of High Energy Physics
In this work we investigate 5-dimensional theories obtained from M-theory on genus one fibered threefolds which exhibit twisted algebras in their fibers.
Lara B. Anderson, James Gray, Paul-Konstantin Oehlmann   +2 more
doaj   +1 more source

Computing the elliptic genus of higher rank E-strings from genus 0 GW invariants

Journal of High Energy Physics, 2019
We show that the elliptic genus of the higher rank E-strings can be computed based solely on the genus 0 Gromov-Witten invariants of the corresponding elliptic geometry.
Zhihao Duan, Jie Gu, Amir-Kian Kashani-Poor   +2 more
doaj   +1 more source

Toric Construction of Global F-Theory GUTs

, 2011
We systematically construct a large number of compact Calabi-Yau fourfolds which are suitable for F-theory model building. These elliptically fibered Calabi-Yaus are complete intersections of two hypersurfaces in a six dimensional ambient space. We first
A Klemm, B Andreas, C Beasley, C Beasley, C-M Chen, C-M Chen, Christoph Mayrhofer, D Cox, H Hayashi, H Hayashi, IM Gelfand, J Marsano, J Marsano, J Marsano, J Marsano, J Tate, Johanna Knapp, K Kodaira, LJ Billera, M Alim, M Cvetič, M Kreuzer, M Kreuzer, M Kreuzer, M Kreuzer, Maximilian Kreuzer, Nils-Ole Walliser, R Blumenhagen, R Blumenhagen, R Blumenhagen, T Oda, T Weigand, TW Grimm, TW Grimm, TW Grimm, TW Grimm, W Fulton   +36 more
core   +4 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

On the scarcity of weak coupling in the string landscape

Journal of High Energy Physics, 2018
We study the geometric requirements on a threefold base for the corresponding F-theory compactification to admit a weakly-coupled type IIB limit. We examine both the standard Sen limit and a more restrictive limit, and determine conditions sufficient for
James Halverson, Cody Long, Benjamin Sung   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Foreword

Comptes Rendus. Physique, 2020
Villain, Jacques
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

F-theory Description of 3-String Junction

, 2003
The geometrical description of BPS 3-string junction in the F-theory background is given by lifting a string junction in IIB into F-theory and constructing a holomorphic curve in K3 with respect to a special complex structure of K3. The holomorphic curve
Yang, Fu-Zhong
core   +3 more sources