Results 171 to 180 of about 15,537,269 (305)
Implications of the Holst term in a f (R) theory with torsion
, 2019 We analyze a modified f(R) theory of gravity in the Palatini formulation, when a Holst term endowed with a dynamical Immirzi field is included. We study the basic features of the model, especially in view of eliminating the torsion field via the Immirzi ...
Bombacigno F., Montani G.
core +1 more source
Proceedings of Theoretical Advanced Study Institute Summer School 2017 "Physics at the Fundamental Frontier" — PoS(TASI2017), 2018 openaire +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
On Abelian Gauge Symmetries and Proton Decay in Global F-theory GUTs [PDF]
, 2010 The existence of abelian gauge symmetries in four-dimensional F-theory compactifications depends on the global geometry of the internal Calabi-Yau fourfold and has important phenomenological consequences.
Weigand, Timo, Grimm, Thomas W.
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The hyperplane string, RCFTs, and the swampland
Journal of High Energy PhysicsSix dimensional N $$ \mathcal{N} $$ = (1, 0) supergravity features BPS strings whose properties encode highly nontrivial information about the parent 6d theory.
Guglielmo Lockhart, Luca Novelli
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source