Results 171 to 180 of about 11,553,390 (309)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Implications of the Holst term in a f (R) theory with torsion
, 2019 We analyze a modified f(R) theory of gravity in the Palatini formulation, when a Holst term endowed with a dynamical Immirzi field is included. We study the basic features of the model, especially in view of eliminating the torsion field via the Immirzi ...
Bombacigno F., Montani G.
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
We compute the couplings of Ramond-Ramond four-form axions in three ensembles of F-theory compactifications, with up to 181,200 axions. We work in the stretched Kähler cone, where $α'$ corrections are plausibly controlled, and we use couplings to certain non-Abelian sectors as a proxy for couplings to photons.
Fallon, Sebastian Vander Ploeg +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Proceedings of Theoretical Advanced Study Institute Summer School 2017 "Physics at the Fundamental Frontier" — PoS(TASI2017), 2018 openaire +1 more source
On Abelian Gauge Symmetries and Proton Decay in Global F-theory GUTs [PDF]
, 2010 The existence of abelian gauge symmetries in four-dimensional F-theory compactifications depends on the global geometry of the internal Calabi-Yau fourfold and has important phenomenological consequences.
Weigand, Timo, Grimm, Thomas W.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The hyperplane string, RCFTs, and the swampland
Journal of High Energy PhysicsSix dimensional N $$ \mathcal{N} $$ = (1, 0) supergravity features BPS strings whose properties encode highly nontrivial information about the parent 6d theory.
Guglielmo Lockhart, Luca Novelli
doaj +1 more source