Results 151 to 160 of about 16,257,561 (327)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Environmental Research Letters, 2019 While many developed countries are increasing their forest cover, deforestation is still rife in the tropics and subtropics. With international trade in forest-risk commodities on the rise, it is becoming increasingly important to consider between ...
Florence Pendrill +3 more
doaj +1 more source
Saddle point inflation from f(R) theory
Physics Letters B, 2015 We analyse several saddle point inflationary scenarios based on power-law f(R) models. We investigate inflation resulting from f(R)=R+αnM2(1−n)Rn+αn+1M−2nRn+1 and f(R)=∑nlαnM2(1−n)Rn as well as l→∞ limit of the latter. In all cases we have found relation
Michał Artymowski +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On the frozen F-theory landscape
Journal of High Energy PhysicsWe study 6d $$\mathcal{N}$$ = (1, 0) supergravity theories arising in the frozen phase of F-theory. For each of the known global models, we construct an F-theory compactification in the unfrozen phase with an identical non-abelian gauge algebra and ...
David R. Morrison, Benjamin Sung
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The toric SO(10) F-theory landscape
Journal of High Energy Physics, 2017 Supergravity theories in more than four dimensions with grand unified gauge symmetries are an important intermediate step towards the ultraviolet completion of the Standard Model in string theory.
W. Buchmüller +3 more
doaj +1 more source
Brane instantons and fluxes in F-theory
, 2013 We study the combined effect of world-volume and background fluxes on Euclidean D3-brane instantons in F-theory compactifications. We derive an appropriate form of the fermionic effective action, in which the fermions are topologically twisted and the ...
Bianchi, Massimo +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Yukawa hierarchies in global F-theory models
Journal of High Energy Physics, 2020 We argue that global F-theory compactifications to four dimensions gener- ally exhibit higher rank Yukawa matrices from multiple geometric contributions known as Yukawa points.
Mirjam Cvetič +4 more
doaj +1 more source