Results 141 to 150 of about 16,257,561 (327)
Journal of High Energy Physics, 2009 In this note, a procedure is developed to explicitly construct non-trivial F-theory lifts of perturbative IIB orientifold models on Calabi-Yau complete intersections in toric varieties. This procedure works on Calabi-Yau orientifolds where the involution coordinate can have arbitrary projective weight, as opposed to the well-known hypersurface cases ...
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
When rational sections become cyclic — Gauge enhancement in F-theory via Mordell-Weil torsion
Journal of High Energy Physics, 2018 We explore novel gauge enhancements from abelian to non-simply-connected gauge groups in F-theory. To this end we consider complex structure deformations of elliptic fibrations with a Mordell-Weil group of rank one and identify the conditions under which
Florent Baume +3 more
doaj +1 more source
An Exceptional Sector for F-theory GUTs
, 2010 D3-branes are often a necessary ingredient in global compactifications of F-theory. In minimal realizations of flavor hierarchies in F-theory GUT models, suitable fluxes are turned on, which in turn attract D3-branes to the Yukawa points.
Cumrun Vafa +2 more
core +1 more source
We compute the couplings of Ramond-Ramond four-form axions in three ensembles of F-theory compactifications, with up to 181,200 axions. We work in the stretched Kähler cone, where $α'$ corrections are plausibly controlled, and we use couplings to certain non-Abelian sectors as a proxy for couplings to photons.
Fallon, Sebastian Vander Ploeg +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Abelian F-theory models with charge-3 and charge-4 matter
Journal of High Energy Physics, 2018 This paper analyzes U(1) F-theory models admitting matter with charges q = 3 and 4. First, we systematically derive a q = 3 construction that generalizes the previous q = 3 examples.
Nikhil Raghuram
doaj +1 more source