Results 121 to 130 of about 15,537,269 (305)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Higher-Derivative Corrected Black Holes: Perturbative Stability and Absorption Cross-Section in Heterotic String Theory [PDF]
, 2006 This work addresses spherically symmetric, static black holes in higher-derivative stringy gravity. We focus on the curvature-squared correction to the Einstein-Hilbert action, present in both heterotic and bosonic string theory.
Schiappa, R. +3 more
core +1 more source
Saddle point inflation from f(R) theory
Physics Letters B, 2015 We analyse several saddle point inflationary scenarios based on power-law f(R) models. We investigate inflation resulting from f(R)=R+αnM2(1−n)Rn+αn+1M−2nRn+1 and f(R)=∑nlαnM2(1−n)Rn as well as l→∞ limit of the latter. In all cases we have found relation
Michał Artymowski +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Origin of Abelian Gauge Symmetries in Heterotic/F-theory Duality [PDF]
, 2015 We study aspects of heterotic/F-theory duality for compactifications with Abelian gauge symmetries. We consider F-theory on general Calabi-Yau manifolds with a rank one Mordell-Weil group of rational sections.
Antonella Grassi +9 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The toric SO(10) F-theory landscape
Journal of High Energy Physics, 2017 Supergravity theories in more than four dimensions with grand unified gauge symmetries are an important intermediate step towards the ultraviolet completion of the Standard Model in string theory.
W. Buchmüller +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
F-theory vacua with $\mathbb Z_3$ gauge symmetry [PDF]
, 2015 Discrete gauge groups naturally arise in F-theory compactifications on genus-one fibered Calabi-Yau manifolds. Such geometries appear in families that are parameterized by the Tate-Shafarevich group of the genus-one fibration.
Piragua, Hernan +9 more
core +1 more source