Results 101 to 110 of about 16,274,002 (260)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Type IIB flux vacua from M-theory via F-theory
, 2009 We study in detail some aspects of duality between type IIB and M-theory. We focus on the duality between type IIB string theory on K3 x T-2/Z(2) orientifold and M-theory on K3 x K3, in the F-theory limit.
VALANDRO, ROBERTO
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Modular family symmetry in F-Theory GUTs from the bottom-up
Finite modular family symmetry can emerge from top-down approaches based on heterotic string theory or Type IIB string theory. We show that, in addition to such approaches, it can also emerge from local F-Theory bottom-up constructions.
Basiouris, Vasileios +3 more
core +1 more source
, 2018 F-theory is probably the most general currently available approach to study non-perturbative string compactifications in their geometric, large radius regime.
Weigand, Timo, Timo Weigand
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Exotic Representations in Abelian and Non-abelian F-theory Models
, 2018 While F-theory models readily admit relatively simple representations, it is difficult to construct models with “exotic” representations that go beyond these simple types.
Raghuram, Nikhil
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
On the Heterotic/F-Theory Duality in Eight Dimensions [PDF]
, 1999 We review quantitative tests on the duality between the heterotic string on T^2 and F-theory on K3. On the heterotic side, certain threshold corrections to the effective action can be exactly computed at one-loop order, and the issue is to reproduce ...
Lerche, W.
core