Results 91 to 100 of about 16,274,002 (260)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The toric SO(10) F-theory landscape

Journal of High Energy Physics, 2017
Supergravity theories in more than four dimensions with grand unified gauge symmetries are an important intermediate step towards the ultraviolet completion of the Standard Model in string theory.
W. Buchmüller, M. Dierigl, P.-K. Oehlmann, F. Rühle   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Twisted Fibrations in M/F-theory

Journal of High Energy Physics
In this work we investigate 5-dimensional theories obtained from M-theory on genus one fibered threefolds which exhibit twisted algebras in their fibers.
Lara B. Anderson, James Gray, Paul-Konstantin Oehlmann   +2 more
doaj   +1 more source

Computing the elliptic genus of higher rank E-strings from genus 0 GW invariants

Journal of High Energy Physics, 2019
We show that the elliptic genus of the higher rank E-strings can be computed based solely on the genus 0 Gromov-Witten invariants of the corresponding elliptic geometry.
Zhihao Duan, Jie Gu, Amir-Kian Kashani-Poor   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

On the scarcity of weak coupling in the string landscape

Journal of High Energy Physics, 2018
We study the geometric requirements on a threefold base for the corresponding F-theory compactification to admit a weakly-coupled type IIB limit. We examine both the standard Sen limit and a more restrictive limit, and determine conditions sufficient for
James Halverson, Cody Long, Benjamin Sung   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Non-supersymmetric F-theory compactifications on Spin(7) manifolds [PDF]

, 2013
We propose a novel approach to obtain non-supersymmetric four-dimensional effective actions by considering F-theory on manifolds with special holonomy Spin(7). To perform such studies we suggest that a duality relating M-theory on a certain class of Spin(
Bonetti, Federico, Federico Bonetti, Grimm, Thomas W., Thomas W. Grimm, Pugh, Tom G., Tom G. Pugh, Sub String Theory Cosmology and ElemPart, Theoretical Physics   +7 more
core   +1 more source