Results 111 to 120 of about 11,553,390 (309)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Abelian F-theory models with charge-3 and charge-4 matter
Journal of High Energy Physics, 2018 This paper analyzes U(1) F-theory models admitting matter with charges q = 3 and 4. First, we systematically derive a q = 3 construction that generalizes the previous q = 3 examples.
Nikhil Raghuram
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Higher-form symmetries and their anomalies in M-/F-theory duality
, 2021 We explore higher-form symmetries of M- and F-theory compactified on elliptic fibrations, determined by the topology of their asymptotic boundaries. The underlying geometric structures are shown to be equivalent to known characterizations of the gauge ...
Zhang, Hao Y. +3 more
core +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
, 2020 We propose 4-point S-matrices for three-dimensional F-theory. We will use the twistor formalism to facilitate constructing the amplitude. We write the amplitude in a way such that the F-symmetry (U-duality symmetry) is manifest. The amplitude can be schematically written as $A_{4} = w^{4}/stu$, where $w$ is an analog of the linearized Weyl tensor in F ...
Siegel, Warren, Wang, Yu-Ping
openaire +2 more sources
Saddle point inflation from f(R) theory
Physics Letters B, 2015 We analyse several saddle point inflationary scenarios based on power-law f(R) models. We investigate inflation resulting from f(R)=R+αnM2(1−n)Rn+αn+1M−2nRn+1 and f(R)=∑nlαnM2(1−n)Rn as well as l→∞ limit of the latter. In all cases we have found relation
Michał Artymowski +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Proceedings of Proceedings of the Corfu Summer Institute 2014 — PoS(CORFU2014), 2015 In this lecture, an overview of current F-theory model building techniques is presented. In F-theory GUT symmetries are associated to the singularities of the elliptically fibred internal (compact) space. Models with gauge groups emerging as subgroups of the exceptional group E8 are presented. Moreover, GUTs with abelian and discrete symmetries arising
openaire +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source