Results 111 to 120 of about 16,274,002 (260)
, 2002 Досліджено спектри BPS-станів в F-теорії на еліптичних розшарованих фоурфолдах.The spectra of BPS states in F-theory on elliptic fibered fourfolds are ...
Обиход, Т.В. +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Non-Abelian discrete gauge symmetries in F-theory
, 2016 The presence of non-Abelian discrete gauge symmetries in four-dimensional F-theory compactifications is investigated. Such symmetries are shown to arise from seven-brane configurations in genuine F-theory settings without a weak string coupling ...
Sub String Theory Cosmology and ElemPart +4 more
core
Viable and stable compact stars in $$f({\mathcal {Q}})$$ f ( Q ) theory
European Physical Journal C: Particles and FieldsIn this paper, we study the viability and stability of anisotropic compact stars in the context of $$f({\mathcal {Q}})$$ f ( Q ) theory, where $${\mathcal {Q}}$$ Q is non-metricity scalar.
Muhammad Zeeshan Gul +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Implications of vanishing complexity condition in $$f({\textbf{R}})$$ f ( R ) theory
European Physical Journal C: Particles and FieldsThis paper introduces the concept of complexity for a static spherical spacetime and extends it to the modified $$f({\textbf{R}})$$ f ( R ) framework. The formulation of the corresponding field equations is then carried out to describe the anisotropic ...
Tayyab Naseer, M. Sharif
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Testing the \(f(R)\)-theory of Gravity [PDF]
, 2019 A procedure of testing the \(f(R)\)-theory of gravity is discussed. The latter is an extension of the general theory of relativity (GR). In order this extended theory (in some variant) to be really confirmed as a more precise theory it must be tested ...
Ky, Nguyen Anh +2 more
core +1 more source