Results 111 to 120 of about 15,537,269 (305)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Universality in a Large Ensemble of F-theory Geometries
, 2018 I will introduce a large ensemble of F-theory geometries, generated by crepant base-changes. I will discuss how understanding the construction algorithm allows us to read off universal behavior in this ensemble, and comment on what this behavior means ...
Long, Cody
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
When rational sections become cyclic — Gauge enhancement in F-theory via Mordell-Weil torsion
Journal of High Energy Physics, 2018 We explore novel gauge enhancements from abelian to non-simply-connected gauge groups in F-theory. To this end we consider complex structure deformations of elliptic fibrations with a Mordell-Weil group of rank one and identify the conditions under which
Florent Baume +3 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Five-Brane Superpotentials and Heterotic/F-theory Duality [PDF]
, 2010 Under heterotic/F-theory duality it was argued that a wide class of heterotic five-branes is mapped into the geometry of an F-theory compactification manifold.
Ha, Tae-Won +5 more
core +1 more source
Abelian F-theory models with charge-3 and charge-4 matter
Journal of High Energy Physics, 2018 This paper analyzes U(1) F-theory models admitting matter with charges q = 3 and 4. First, we systematically derive a q = 3 construction that generalizes the previous q = 3 examples.
Nikhil Raghuram
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Proceedings of Proceedings of the Corfu Summer Institute 2014 — PoS(CORFU2014), 2015 In this lecture, an overview of current F-theory model building techniques is presented. In F-theory GUT symmetries are associated to the singularities of the elliptically fibred internal (compact) space. Models with gauge groups emerging as subgroups of the exceptional group E8 are presented. Moreover, GUTs with abelian and discrete symmetries arising
openaire +1 more source