Results 41 to 50 of about 401,434 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Image Matching by Using Fuzzy Transforms
Advances in Fuzzy Systems, 2013 We apply the concept of Fuzzy Transform (for short, F-transform) for improving the results of the image matching based on the Greatest Eigen Fuzzy Set (for short, GEFS) with respect to max-min composition and the Smallest Eigen Fuzzy Set (for short, SEFS)
Ferdinando Di Martino, Salvatore Sessa
doaj +1 more source
Axioms, 2019 The main ideas of F-transform came from representing expert rules. It would be therefore reasonable to expect that the more accurately the membership functions describe human reasoning, the more successful will be the corresponding F-transform formulas ...
Olga Kosheleva +2 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Generalized integral Laplace transform and its application to solving some integral equations
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014 We present integral transforms $\widetilde {\mathcal L}\left\{f(t);x\right\}$ and $\widetilde {\mathcal L}_{\gamma_1,\gamma_2,\gamma} \left\{f(t);x\right\}$, generalizing the classical Laplace transform.
Svetlana M Zaikina
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Injectivity sets of the spherical mean operator with respect to the Bessel convolution [PDF]
Известия Саратовского университета. Новая серия: Математика. Механика. ИнформатикаLet $C_\natural$ be the set of all even continuous functions on the real axis, $E$ be a non-empty set on $(0,+\infty)$, $\mathcal{R} f(x,t)$ be the spherical mean of the function $f\in C_\natural$ with center at the point $x\in E$ and radius $t>0 ...
Krasnoschekikh, Gleb Vitalievich +1 more
doaj +1 more source