Results 11 to 20 of about 43,617 (281)
Zhongshan Daxue xuebao. Yixue kexue ban, 2009 【目的】 确定F10基因表达对细胞生长的影响,明确F10基因的功能。 【方法】 构建F10基因的真核表达载体,转染重组pRc-CMV2-F10质粒于肺癌细胞系A549, 筛选并获得稳定表达F10基因的细胞克隆A549-F10。通过MTT实验和流式细胞检测F10对细胞生长的影响;通过免疫组化检测细胞中增殖核抗原(PCNA)和细胞周期素D1(cyclin D1)的表达。【结果】 转基因的G418抗性克隆能够检测到F10表达。MTT和流式结果显示F10有促进细胞增殖的作用 ...
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Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation. [PDF]
Adv Sci (Weinh)BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Dai H +7 more
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Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor-Associated Macrophages. [PDF]
Adv Sci (Weinh)Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Luo B, Qiu L.
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Saudi Pharmaceutical Journal, 2018 STAT3 knockdown by small interfering RNA (siRNA) has been described to inhibit carcinogenic growth in various types of tumors. Earlier we have reported delivery of siRNA by oleic acid- and stearic acid-modified-polyethylenimine and enhancement of ...
Aws Alshamsan
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Impact of Financial Liberalization on Export: Evidence from Kosovo
Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2023 The current study observes the link between export levels, GDP growth, gross savings, lending interest rates, and real interest rates. This study's evaluation approach combines an Ordinary Least Squares (OLS), and Arrellano-Bover/Blundell-Bond estimation
Spahiu Muhamet J., Durguti Esat A.
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Learning and Timing of Voluntary Blink Responses Match Eyeblink Conditioning
Scientific Reports, 2017 Can humans produce well-timed blink responses to a neutral stimulus voluntarily, without receiving any blink-eliciting, unconditional, stimulus? And if they can, to what degree does classical eyeblink conditioning depend on volition?
Anders Rasmussen, Dan-Anders Jirenhed
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CD8+ T cell memory is sustained in mice by hepatic stellate cells
Hepatology, EarlyView., 2022 HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen +4 more
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Spatial analysis from remotely sensed observations of Congo basin of East African high Land to drain water using gravity for sustainable management of low laying Chad basin of Central Africa [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014 The Chad basin which covers an area of about 2.4 million kilometer square is one of the largest drainage basins in Africa in the centre of Lake Chad .This basin was formed as a result of rifting and drifting episode, as such it has no outlet to the ...
B. Modu, B. Herbert
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