Results 201 to 210 of about 131,324 (287)

Integrative single‐cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical highlights Tumour subpopulations with high malignancy show reduced interferon signalling and reduced MHC‐I expression. Tumour‐associated macrophages (TAMs) differentiate into two opposing states: SPP1+ TAMs and CXCL9+ TAMs. Among immune ecotypes, T‐cell‐enriched ecotypes are linked with high MHC‐I expression in tumour cells while desert ...
Lingjuan Huang   +13 more
wiley   +1 more source

A selective RPL15 PROTAC degrader enhances anti-PD-1 immunotherapy in a murine melanoma tumor model. [PDF]

open access: yesOncogene
Takahashi R   +11 more
europepmc   +1 more source

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross‐Presentation

open access: yesEuropean Journal of Immunology, Volume 56, Issue 2, February 2026.
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Alice Senni   +7 more
wiley   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

open access: yesJournal of Applied Toxicology, Volume 46, Issue 2, Page 682-696, February 2026.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros   +16 more
wiley   +1 more source

Sexual Experience, Psychological Implications, and Typical Response Strategies Among Childhood Cancer Survivors With Sexual Dysfunction in China: A Qualitative Study

open access: yesPsycho-Oncology, Volume 35, Issue 2, February 2026.
ABSTRACT Background Sexual dysfunction is a well‐documented long‐term side effect of pediatric cancer treatment, which significantly impacts the overall health of childhood cancer survivors (CCSs). There is a relative lack of qualitative research on sexual dysfunction among CCSs. Aim This study aimed to explore sexual experience, psychological factors,
Funa Yang   +15 more
wiley   +1 more source

Oncolytic Newcastle-disease-virus-mediated CD47 blockade in preclinical melanoma and pancreatic cancer models. [PDF]

open access: yesMol Ther Oncol
Yates JGE   +10 more
europepmc   +1 more source

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