Results 141 to 150 of about 2,095 (173)
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The c-Ring of the F1FO-ATP Synthase: Facts and Perspectives
The Journal of Membrane Biology, 2015The F1FO-ATP synthase is the only enzyme in nature endowed with bi-functional catalytic mechanism of synthesis and hydrolysis of ATP. The enzyme functions, not only confined to energy transduction, are tied to three intrinsic features of the annular arrangement of c subunits which constitutes the so-called c-ring, the core of the membrane-embedded FO ...
NESCI, SALVATORE +3 more
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F1Fo adenosine triphosphate (ATP) synthase is a potential drug target in non-communicable diseases
Molecular Biology Reports, 2023F1Fo adenosine triphosphate (ATP) synthase, also known as the complex V, is the central ATP-producing unit in the cells arranged in the mitochondrial and plasma membranes. F1Fo ATP synthase also regulates the central metabolic processes in the human body driven by proton motive force (Δp). Numerous studies have immensely contributed toward highlighting
Varsha Singh, Singh Varsha
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Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions
Current Opinion in Lipidology, 2006Until recently, F1Fo ATP synthase expression was believed to be strictly confined to mitochondria where it generates most cellular ATP. This paper reviews the recent evidence for an extra-mitochondrial expression of its components by immunofluorescence, biochemistry and proteomics studies.
Eric, Champagne +3 more
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Evolution and regulatory diversification of plastid F1FO-ATP synthase
Plant and Cell PhysiologyAbstract F1FO-ATP synthase, the enzyme complex responsible for adenosine triphosphate (ATP) production, is universally conserved and central to cellular energy metabolism in bacteria as well as in mitochondria and plastids—organelles derived from ancestral bacteria.
Kaori Kohzuma +3 more
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Journal of Molecular Biology, 2007
The Oxa1 protein is a founding member of the evolutionarily conserved Oxa1/Alb3/YidC protein family, which is involved in the biogenesis of membrane proteins in mitochondria, chloroplasts and bacteria. The predicted human homologue, Oxa1l, was originally identified by partial functional complementation of the respiratory growth defect of the yeast oxa1
Lukas, Stiburek +5 more
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The Oxa1 protein is a founding member of the evolutionarily conserved Oxa1/Alb3/YidC protein family, which is involved in the biogenesis of membrane proteins in mitochondria, chloroplasts and bacteria. The predicted human homologue, Oxa1l, was originally identified by partial functional complementation of the respiratory growth defect of the yeast oxa1
Lukas, Stiburek +5 more
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Energy Transduction by the Two Molecular Motors of the F1Fo ATP Synthase
2011The F1Fo ATP synthase has nearly universal importance as the major source of ATP among all life forms. These molecular motors couple the energy provided by a transmembrane proton gradient to the production of ATP from ADP and phosphate. The intrinsic membrane complex of ab2c10–15 subunits, known as Fo, functions as a proton channel via a Brownian ...
David Spetzler +6 more
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Cryo-EM structure of Chlamydomonas reinhardtii chloroplast F1Fo-ATP synthase
Biochemical and Biophysical Research CommunicationsF1Fo-ATP synthase is a multi-subunit energy-producing macromolecular machine, consisting of hydrophilic F1 and hydrophobic Fo segments, which utilize transmembrane electrochemical potential to synthesize ATP from ADP and inorganic phosphate. ATP synthases are widely distributed in the inner membrane of mitochondria, the thylakoid membrane of ...
Jian, Liu +5 more
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Current Medicinal Chemistry, 2011
Throughout our lifetime the F1Fo ATP synthase produces the majority of our biological energy, and plays central roles in the structure and organization of mitochondria, yet our understanding of its roles in human disease remain largely enigmatic. It seems logical that even intermittent impairment of this highly important enzyme could deprive the body's
J A, Johnson, Mourad, Ogbi
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Throughout our lifetime the F1Fo ATP synthase produces the majority of our biological energy, and plays central roles in the structure and organization of mitochondria, yet our understanding of its roles in human disease remain largely enigmatic. It seems logical that even intermittent impairment of this highly important enzyme could deprive the body's
J A, Johnson, Mourad, Ogbi
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The mitochondrial F1Fo ATP synthase
2007Adenosine triphosphate (ATP) is the general energy currency of living organisms from simple prokaryotes to the more complex eukaryotes. It is continually produced at the expense of nutrients and utilized by endergonic biological processes in large amounts that usually exceed the weight of the organism.
Gaballo A, Papa S
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Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014F1FO ATP synthases catalyze the synthesis of ATP from ADP and inorganic phosphate driven by ion motive forces across the membrane. A number of ATP synthases have been characterized to date. The one from the hyperthermophilic bacterium Aquifex aeolicus presents unique features, i.e. a putative heterodimeric stalk.
Zhang, C. +6 more
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