Results 41 to 50 of about 17,763 (210)
A DARPin promotes faster onset of botulinum neurotoxin A1 action
Nature Communications, 2023 In this study, we characterize Designed Ankyrin Repeat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin A1 (BoNT/A1) structure and function. We identify DARPin-F5 that completely blocks SNAP25 substrate cleavage by BoNT/A1 in vitro.
Oneda Leka +10 more
doaj +1 more source
B(C6 F5 )3 -Enabled Synthesis of a Cyclic cis-Arsaphosphene.
Chemistry, 2019 The synthesis and characterization of an (arsino)phosphaketene, As(PCO){[N(Dipp)](CH2 )}2 (Dipp=2,6-diisopropylphenyl) is reported along with its subsequent reactivity with B(C6 F5 )3 .
Meera Mehta, J. McGrady, J. Goicoechea
semanticscholar +1 more source
Asymmetry in Skipping Enhances Viability Against Control Input Noise
Advanced Robotics Research, EarlyView.Quadruped animals use asymmetric galloping gaits at high speeds, yet the functional role of this asymmetry remains unclear. This study shows that left–right asymmetry in touchdown angles enhances robustness to control noise. Using a simple two‐legged locomotion model and viability theory, it demonstrates that asymmetric skipping substantially enlarges ...
Yuichi Ambe, Alvin So, Shinya Aoi
wiley +1 more source
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2022 Background: Cancer is considered one of the most lethal diseases worldwide. Venous thromboembolism (VTE) is the second leading cause of death in cancer patients. As one of the most reproducible predictors of thromboembolism, the D-dimer level is commonly
Yiming Guan +12 more
doaj +1 more source
Advanced Science, EarlyView.To accelerate the inverse design of heterostructured metal matrix composites, a closed‐loop scientific machine learning framework integrates continual learning prediction with NSGA‐II‐PMCP optimization. The framework maps microstructural descriptors to strength, toughness, and modulus, expands high‐quality Pareto solutions, and guides experimentally ...
Zhiyan Zhong +11 more
wiley +1 more source
F5-peptide enhances the efficacy of the non-hormonal male contraceptive adjudin
Contraception, 2019 Objective. The bioavailability of the non-hormonal male contraceptive adjudin is low in rats due to the blood-testis barrier (BTB). This study was designed to examine if F5-peptide, an endogenously produced reversible BTB modifier, could enhance the ...
Haiqi Chen +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.By altering surface chemical bonds to prolong relaxation time and shift absorption to lower frequencies, SiC/rare earth–sulfur (RE─S, RE = La, Ce, Pr, Sm, Gd, Er) materials achieve excellent low‐frequency electromagnetic wave absorption under extreme conditions, offering a new direction for designing high‐performance SiC‐based absorbers.
Zhanming Wu +5 more
wiley +1 more source
Effects of Feeding Frequency for Nile Tilapia Fingerlings (Oreochromis niloticus)
Aquaculture Nutrition, 2022 This study is aimed at assessing the feeding frequency for tilapia fingerlings. 240 fishes were randomly distributed in 24 containers. The feeding consisted of six frequencies: 4 (F4), 5 (F5), 6 (F6), 7 (F7), 8 (F8), and 9 (F9) times a day.
Aldo Felipe Fava +7 more
doaj +1 more source
Advanced Science, EarlyView.This study elucidates the phase transition pathway of surface‐engineered perovskite films. During spin‐coating, n = 1 2D perovskite dominantly forms, while subsequent annealing drives OA+ release and induces conversion to higher n‐value 2D phases.
Yajie Yang +12 more
wiley +1 more source