CD4+TGFβ+ cells infiltrated the bursa of Fabricius following IBDV infection, and correlated with a delayed viral clearance, but did not correlate with disease severity, or immunosuppression [PDF]
Frontiers in Immunology, 2023 IntroductionInfectious Bursal Disease Virus (IBDV) causes immunosuppression in chickens. While B-cell destruction is the main cause of humoral immunosuppression, bursal T cells from IBDV-infected birds have been reported to inhibit the mitogenic response
Salik Nazki +10 more
doaj +2 more sources
Ligand-driven modulation of chaperone-cochaperone networks shapes proteostasis outcomes. [PDF]
Protein SciAbstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Magni A +9 more
europepmc +2 more sources
Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses [PDF]
Frontiers in Virology, 2023 The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies.
Pradeepa Pushparaj +8 more
doaj +2 more sources
Changes in the Aqueous Solvent do not Impact the Internal Ring-Flip Dynamic of Fully Buried F52 in Protein GB1. [PDF]
ChembiochemThe ring‐flip dynamic in the interior of a protein is independent from changes in the solvent and only depends on the protein itself. Aromatic ring flips are a hallmark of protein dynamics. They are mediated by either transient “breathing” motions in which the protein expands into the solvent or by transient internal rearrangement of void spaces ...
Dreydoppel M +4 more
europepmc +2 more sources
EFSA Journal, 2020 The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, the Netherlands, and co‐rapporteur Member State, France, for ...
László Bura +2 more
exaly +2 more sources
Unlocking the Nutritional Potential of Gamma Amino Butyric Acid (GABA) Rice: Towards a Sustainable Approach to Metabolic Disorder Remedies. [PDF]
Food Sci NutrThis study addresses the critical issue of nutrient deficiencies associated with the widespread consumption of conventional milled rice, which often lacks essential vitamins and minerals due to the removal of the bran layer during processing. It demonstrated that controlled germination of paddy rice, followed by parboiling, substantially increases the ...
Onyeka UE +5 more
europepmc +2 more sources
The science of adapted throws: a systematic search and narrative evidence synthesis [PDF]
Frontiers in Sports and Active LivingIntroductionParalympic throwing events have grown rapidly, yet the scientific evidence guiding technique, training and classification remains fragmented across biomechanics, physiology and psychosocial domains.ObjectiveTo provide an evidence-based ...
Exal Garcia-Carrillo +9 more
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Modeling Infectious Bursal Disease Virus (IBDV) Antigenic Drift In Vitro [PDF]
Viruses, 2022 Infectious bursal disease virus (IBDV) vaccines do not induce sterilizing immunity, and vaccinated birds can become infected with field strains. Vaccine-induced immune selection pressure drives the evolution of antigenic drift variants that accumulate ...
Amin S. Asfor +5 more
doaj +2 more sources
Unlocking the in vitro and in vivo antioxidant and anti-inflammatory activities of polysaccharide fractions from Lepidium sativum seed-coat mucilage [PDF]
HeliyonInflammation coupled with oxidative stress contribute to the pathogenicity of various clinical disorders. Oxidative stress arises from an imbalance between production of reactive oxygen species (ROS) and antioxidant defense system, leading to cellular ...
Imdad Ullah Khan +9 more
doaj +2 more sources
On the empirics of violence, inequality, and income
Journal of Economics and Management, 2023 Aim/purpose – This paper aims to examine with new empirical evidence the joint relationships between violence, income inequality, and real income per capita in a simultaneous equation framework using a worldwide sample at the country level.
Gavilanes John Michael Riveros
doaj +1 more source