Results 1 to 10 of about 12,343 (209)

H2O2-propelled Janus nanomotor for synergistic treatment of drug-resistant biofilm infections [PDF]

Journal of Nanobiotechnology
In contemporary antibacterial treatment, the inability to effectively penetrate biofilm structures, coupled with the rising prevalence of antimicrobial resistance, significantly compromise the clinical efficacy of antibiotic-based therapies.
Daifeng Li, Lurui Yang, Liuliang He, Bowen Liu, Yuhui Yuan, Zhichao Wang, Jinjin Shi, Yi Zhang   +7 more
doaj   +2 more sources

In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery [PDF]

International Journal of Pharmaceutics, 2016
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their ...
Wing Man Lau, Vitaliy V Khutoryanskiy
exaly   +2 more sources

Surfactant-Enriched Cross-Linked Scaffold as an Environmental and Manufacturing Feasible Approach to Boost Dissolution of Lipophilic Drugs [PDF]

Pharmaceutics
Background/Objectives: The inherent low aqueous solubility of lipophilic drugs, belonging to Class II based on Biopharmaceutical classification system, negatively impacts their oral bioavailability.
Abdelrahman Y. Sherif, Doaa Hasan Alshora, Mohamed A. Ibrahim   +2 more
doaj   +2 more sources

Tuning Pluronic Hydrogel Networks: Effects of Vancomycin Loading on Gelation, Rheological Properties, and Micellar Structures [PDF]

Gels
Thermoresponsive Pluronic hydrogels offer a promising platform for localised antibiotic delivery. However, how drug loading affects the structural integrity and gelation of these systems remains underexplored.
Michael J. Gaffney, Qi Han, Kate Fox, Nhiem Tran   +3 more
doaj   +2 more sources

Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting

Biomedicine and Pharmacotherapy, 2019
Galangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to its poor aqueous solubility, P-gp efflux and rapid in vivo metabolism by cytochrome enzymes.
Sharvil Patil, Atul S Rathore
exaly   +3 more sources

Production of Protease Inhibitor With Penicillium sp. — Optimization of the Medium for Growth in Pellet Form and Cytotoxicity Testing [PDF]

Engineering in Life Sciences
Penicillium sp. (IBWF 040‐09) produces a protease inhibitor that can potentially be used against the main protease of human African trypanosomiasis. Since the target substance is formed intracellularly (under nutrient limitation), the fungal pellet is ...
Winda Soerjawinata, Shila Prajapati, Isabelle Barth, Xiaohua Lu, Roland Ulber, Thomas Efferth, Percy Kampeis   +6 more
doaj   +2 more sources

Characterization of a Novel POx-Based Adhesive Powder for Obliterating Dead Spaces After Surgery [PDF]

Bioengineering
Surgical dead spaces are challenging to handle with current preventive methods. Tissue adhesives show promise in obliterating ‘dead spaces’, but the drawbacks of currently available adhesives prevent them from being used for dead space elimination.
Steven E. M. Poos, Roger M. L. M. Lomme, Edwin A. Roozen, Johan C. M. E. Bender, Harry van Goor, Richard P. G. Ten Broek   +5 more
doaj   +2 more sources

Exploring the potential of a thermosensitive in situ gel with Periplaneta americana extracts for efficient wound healing [PDF]

Frontiers in Pharmacology
The primary aim of this study was to fabricate a wound healing thermosensitive in situ gel containing Periplaneta americana extract (PAE), which is widely utilized clinically due to its anti-inflammatory and skin regeneration effects. The thermosensitive
Shuai Liu, Shuohan Xu, Hang Lu, Xueyu Gong, Huaipeng Li, Xinyu Fan, Hongwei Yang   +6 more
doaj   +2 more sources

Development of a Versatile Nanostructured Lipid Carrier (NLC) Using Design of Experiments (DoE)—Part II: Incorporation and Stability of Butamben with Different Surfactants [PDF]

Pharmaceutics
Nanostructured lipid carriers (NLCs) are typically composed of liquid lipids, solid lipids, and surfactants, enabling the encapsulation of lipophilic drugs. Butamben is a Class II anesthetic drug, according to the Biopharmaceutical Classification System (
Ananda P. Matarazzo, Carlos A. Rios, Gabriela Gerônimo, Roberta Ondei, Eneida de Paula, Márcia C. Breitkreitz   +5 more
doaj   +2 more sources

Bakuchiol-Loaded F127/F68 Thermosensitive Hydrogel For Periodontitis Treatment

International Dental Journal
Aim or purpose: Bakuchiol (Bak), a natural compound from Psoralea corylifolia L. seeds, exhibits antibacterial, anti-inflammatory, and osteogenic properties.
Wenying Huang, Zhang Kailiang, Yin Xiupei, Tong Chunfeng   +3 more
doaj   +2 more sources