Results 1 to 10 of about 5,596 (186)

Storage and Stability of AAV-Containing Fibrin Hydrogels for Retinal Gene Therapy [PDF]

Gels
Subretinal and intravitreal injection of retinal gene therapy is associated with serious adverse events and poor efficacy. We sought to improve retinal gene therapy delivery by developing fibrin hydrogel encapsulated adeno-associated virus (FE-AAV). Here
Aubrey Berger, Travis Knudsen, Francesca Kopp, David Korda, Mary Lang, Brittni A. Scruggs, Alan D. Marmorstein   +6 more
doaj   +2 more sources

Heat Perceptions, Behaviors, and Barriers of Unhoused Individuals in Germany [PDF]

Public Health Chall
Across in‐depth interviews and a survey of 252 unhoused people in 13 German cities, many underestimated heat risks yet often experienced heat‐related fatigue, nausea, or faintness. Participants reported limited hydration and frequent eviction from cooling spots, heat‐aggravating medication whose dosage and storage were rarely adapted, and minimal sun ...
Sprengholz P, Bruckmann R, Daniel L, Else E, Moreth L, Piatti N.   +5 more
europepmc   +2 more sources

H2O2-propelled Janus nanomotor for synergistic treatment of drug-resistant biofilm infections [PDF]

Journal of Nanobiotechnology
In contemporary antibacterial treatment, the inability to effectively penetrate biofilm structures, coupled with the rising prevalence of antimicrobial resistance, significantly compromise the clinical efficacy of antibiotic-based therapies.
Daifeng Li, Lurui Yang, Liuliang He, Bowen Liu, Yuhui Yuan, Zhichao Wang, Jinjin Shi, Yi Zhang   +7 more
doaj   +2 more sources

Wearable OLED-Assisted Photodynamic Cancer Therapy Using Chlorin e6-Loaded Pluronic Nanocapsules as Photosensitizers. [PDF]

Adv Healthc Mater
A novel photodynamic therapeutic approach has been employed for anticancer therapy, utilizing chlorin e6‐loaded Pluronic nanocapsules and a wearable organic light‐emitting diode light source. This has shown significant in vivo antitumor efficacy with minimal off‐target toxicity. The innovative combination of a wearable light source and photosensitizers
Oh H, Jeong SM, Park CH, Son P, Lee Y, Koo H, Choi WI, Choi KC.   +7 more
europepmc   +2 more sources

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli-responsive controlled release. [PDF]

Smart Mol
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Al-Amili M, Lei L, Jin Z.
europepmc   +2 more sources

Surfactant-Enriched Cross-Linked Scaffold as an Environmental and Manufacturing Feasible Approach to Boost Dissolution of Lipophilic Drugs [PDF]

Pharmaceutics
Background/Objectives: The inherent low aqueous solubility of lipophilic drugs, belonging to Class II based on Biopharmaceutical classification system, negatively impacts their oral bioavailability.
Abdelrahman Y. Sherif, Doaa Hasan Alshora, Mohamed A. Ibrahim   +2 more
doaj   +2 more sources

Design and Characterization of Dual-Modal Fluorinated BODIPY Probes. [PDF]

Chempluschem
Here we show a fluorinated BODIPY dye that combine 19F traceability with photoluminescence, properly designed to reduce aggregation‐induced quenching and to adjust the packing in condensed environments. The molecule can be encapsulated in Pluronic F68‐stabilized poly(lactic‐co‐glycolic acid) nanoparticles.
Ayaz N, Rosati M, Damoli M, Perez Rosas JC, Pizzi A, Metrangolo P, Orlandi S, Penconi M, Cavazzini M, Baldelli Bombelli F.   +9 more
europepmc   +2 more sources

Tuning Pluronic Hydrogel Networks: Effects of Vancomycin Loading on Gelation, Rheological Properties, and Micellar Structures [PDF]

Gels
Thermoresponsive Pluronic hydrogels offer a promising platform for localised antibiotic delivery. However, how drug loading affects the structural integrity and gelation of these systems remains underexplored.
Michael J. Gaffney, Qi Han, Kate Fox, Nhiem Tran   +3 more
doaj   +2 more sources

Exploring the potential of a thermosensitive in situ gel with Periplaneta americana extracts for efficient wound healing [PDF]

Frontiers in Pharmacology
The primary aim of this study was to fabricate a wound healing thermosensitive in situ gel containing Periplaneta americana extract (PAE), which is widely utilized clinically due to its anti-inflammatory and skin regeneration effects. The thermosensitive
Shuai Liu, Shuohan Xu, Hang Lu, Xueyu Gong, Huaipeng Li, Xinyu Fan, Hongwei Yang   +6 more
doaj   +2 more sources

Characterization of a Novel POx-Based Adhesive Powder for Obliterating Dead Spaces After Surgery [PDF]

Bioengineering
Surgical dead spaces are challenging to handle with current preventive methods. Tissue adhesives show promise in obliterating ‘dead spaces’, but the drawbacks of currently available adhesives prevent them from being used for dead space elimination.
Steven E. M. Poos, Roger M. L. M. Lomme, Edwin A. Roozen, Johan C. M. E. Bender, Harry van Goor, Richard P. G. Ten Broek   +5 more
doaj   +2 more sources