Poloxamer-Based Scaffolds for Tissue Engineering Applications: A Review
Gels, 2022 Poloxamer is a triblock copolymer with amphiphilicity and reversible thermal responsiveness and has wide application prospects in biomedical applications owing to its multifunctional properties.
Yunhan Sun, Eui Seok Lee, Heng Bo Jiang
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Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin [PDF]
PharmaceuticsBackground/Objectives: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which ...
Thanchanok Sirirak, Thirapit Subongkot
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Injectable Poloxamer Hydrogels for Local Cancer Therapy
Gels, 2023 The widespread push to invest in local cancer therapies comes from the need to overcome the limitations of systemic treatment options. In contrast to intravenous administration, local treatments using intratumoral or peritumoral injections are ...
Costa P +2 more
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Use of factorial design in formulation and evaluation of intrarectal in situ gel of sumatriptan
Journal of Advanced Pharmaceutical Technology & Research, 2023 The study's goal was to create an in situ intrarectal mucoadhesive gel of sumatriptan (SMT) combining mucoadhesive polymer (xyloglucan) and thermosensitive polymers (poloxamer 407 and poloxamer 188) to prolong rectal residence time for treatment of ...
Hanan J Kassab +2 more
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Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery
Brazilian Journal of Pharmaceutical Sciences, 2023 Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs.
Dwianto Harry Nugraha +2 more
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Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole
Pharmaceutics, 2023 Surfactants have been widely used as effective additives to increase the solubility and dissolution rates of amorphous solid dispersions (ASDs). However, they may also generate adverse effects on the physical stability of ASDs.
Jie Zhang +10 more
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Preparation of injectable sodium alginate/ poloxamer composite hydrogel for sustained drug release
Cailiao gongcheng, 2020 Poloxamer is a thermo-sensitive synthetic polymer that can achieve sol-gel transition with temperature change, but its relative molecular mass is low, and the hydrogel structure is difficult to maintain for a long time.
HOU Bing-na +6 more
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New Strategies for Improving Budesonide Skin Retention
Pharmaceutics, 2021 The aim of this work was to evaluate the ex vivo effect of the combination of two strategies, complexation with cyclodextrin, and poloxamer hydrogels, for improving water solubility in the dermal absorption of budesonide.
Cristina Padula +3 more
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Pharmaceutics, 2020 Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain.
Jackson Russo +2 more
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APPROACHES TO THE SELECTION OF EXCIPIENTS FOR DENTAL GEL WITH CETYLPYRIDINIUM CHLORIDE
Фармация и фармакология (Пятигорск), 2021 The aim of the study was to determine the excipients influence on the characteristics of gels with cetylpyridinium chloride and to select the dental gel formulation gelation agents promising for the development of dental gel compositions.
E. Yu. Zagorulko, A. S. Karavaeva
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