Results 11 to 20 of about 16,153 (200)

Thermogelling properties of purified poloxamer 407

Heliyon, 2017
Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks.
Amir Fakhari, Marta Corcoran, Alexander Schwarz   +2 more
doaj   +2 more sources

Accelerating Effects of Poloxamer and Its Structural Analogs on the Crystallization of Nitrendipine Polymorphs

Pharmaceuticals
Background: Surfactants can be added into polymer–amorphous drug systems to further enhance solubility. However, this may cause amorphous drugs to become physically unstable, and the inherent mechanism at play here is not fully understood.
Jie Zhang, Qiusheng Yang, Meixia Xu, Xinqiang Tan, Xucong Peng, Ziqing Yang, Kang Li, Jia Yang, Jie Chen, Xuan Xun, Saijun Xiao, Lingjie Zhou, Minzhuo Liu, Zhihong Zeng   +13 more
doaj   +2 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Poloxamer-enhanced solubility of griseofulvin and its related antifungal activity against Trichophyton spp.

, 2022
Poorly water-soluble drugs, such as the antifungal drug griseofulvin (GF), exhibit limited bioavailability, despite their high membrane permeability. Several technological approaches have been proposed to enhance the water solubility and bioavailability ...
Vanessa Pittol (13030907), Alexandre Meneghello Fuentefria (7511657), George González Ortega (13219382), Samuel Kaiser (767257), Kleyton Santos Veras (13030910), Letícia Jacobi Danielli (12643252)   +5 more
core   +1 more source

Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats [PDF]

International Neurourology Journal, 2019
Purpose Hyperlipidemia, which promotes the development of atherosclerosis, ischemic stroke, and other forms of brain injury, can be induced by poloxamer-407. Berberine is a primary pharmacological active component of Coptidis Rhizoma that has a number of
Mia Kim, Tae-Woon Kim, Chang-Ju Kim, Mal-Soon Shin, Minha Hong, Hye-Sang Park, Sang-Seo Park   +6 more
doaj   +1 more source

Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications

Pharmaceutics, 2021
The current study was designed to convert the poloxamer (PLX) into thiolated poloxamer (TPLX), followed by its physicochemical, biocompatibilities studies, and applications as a pharmaceutical excipient in the development of tacrolimus (TCM)-containing ...
Muhammad Zaman, Sadaf Saeed, Rabia Imtiaz Bajwa, Muhammad Shafeeq Ur Rahman, Saeed Ur Rahman, Muhammad Jamshaid, Muhammad F. Rasool, Abdul Majeed, Imran Imran, Faleh Alqahtani, Sultan Alshehri, Abdullah F. AlAsmari, Nemat Ali, Mohammed S. Alasmari   +13 more
doaj   +1 more source

Causative factors behind poloxamer 188 (Pluronic F68, Flocor™)-induced complement activation in human sera A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels [PDF]

, 2004
Poloxamer 188 is a complex polydisperse mixture of non-ionic macromolecules. Adverse non-IgE-mediated hypersensitivity reactions occur in some individuals following intravenous injection of poloxamer 188-based pharmaceuticals, presumably via complement ...
Dadswell, C.M., Moghimi, S.M., Savay, S., Szebeni, J., Hunter, A.C., Alving, C.R.   +5 more
core   +2 more sources

In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

International Journal of Pharmaceutics: X, 2019
The objective of this study was to evaluate in vitro and in vivo drug release from in situ forming gels prepared with poloxamer 338 (P338) and/or 407 (P407) in N-methyl-2-pyrrolidone (NMP)/water mixtures for the model compound bedaquiline fumarate salt ...
Sandy Van Hemelryck, Jonatan Dewulf, Harm Niekus, Marjolein van Heerden, Benno Ingelse, René Holm, Erik Mannaert, Peter Langguth   +7 more
doaj   +1 more source

Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2014
Background: Poloxamer 407 is used in parenteral formulations as solubilizing and wetting agent for traditional, low-molecular-weight organic drug molecules and as stabilizing agent for proteins and polypeptide drugs.
Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi   +5 more
doaj   +1 more source