Review of the novel antifungal drug olorofim (F901318) [PDF]
BMC Infectious DiseasesThere is clearly a need for novel antifungal agents, not only concerning spectrum, but also oral bioavailability, tolerability, and drug-drug interactions.
Robina Aerts +2 more
exaly +6 more sources
F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance New antifungal drugs that act via novel mechanisms are urgently needed to combat the high mortality of invasive fungal disease and the emergence of resistance to existing therapies. We describe the discovery, structure, activity, and mechanism of action of F901318, a new antifungal agent. A member of a novel class of antifungals,
Saskia du Pré +2 more
exaly +9 more sources
Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by Aspergillus flavus [PDF]
Journal of Infectious Diseases, 2018 Aspergillus flavus is one of the most common agents of invasive aspergillosis and is associated with high mortality. The orotomides are a new class of antifungal agents with a novel mechanism of action. An understanding of the pharmacodynamics (PD) of the lead compound F901318 is required to plan safe and effective regimens for clinical use.The ...
Ruwanthi Kolamunnage-Dona +2 more
exaly +11 more sources
Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance [PDF]
Emerging Microbes and Infections, 2022 Olorofim (F901318) is a new antifungal currently under clinical development that shows both in vitro and in vivo activity against a number of filamentous fungi including Aspergillus fumigatus. In this study we screened A. fumigatus isolates for intrinsic
Jochem B Buil +2 more
exaly +3 more sources
Pharmacodynamics of the Orotomides against
mBio, 2017 F901318 is an antifungal agent with a novel mechanism of action and potent activity against Aspergillus spp. An understanding of the pharmacodynamics (PD) of F901318 is required for selection of effective regimens for study in phase II and III clinical ...
William W. Hope +11 more
doaj +5 more sources
Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus [PDF]
Antimicrobial Agents and Chemotherapy, 2018 F901318 (olorofim) is a novel antifungal drug that is highly active against Aspergillus species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway.
Saskia du Pré +2 more
exaly +6 more sources
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus [PDF]
Journal of Fungi, 2020 The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré +7 more
doaj +6 more sources
Review of the Novel Investigational Antifungal Olorofim [PDF]
Journal of Fungi (Basel, Switzerland), 2020 The incidence of invasive fungal infections caused by molds and endemic fungi is increasing. There is also concern regarding increased rates of reduced susceptibility or frank resistance among Aspergillus and Coccidioides species, while Scedosporium ...
Nathan P Wiederhold
exaly +4 more sources
Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Olorofim (F901318), a Novel Antifungal Drug, in Human Plasma and Serum [PDF]
Antimicrobial Agents and Chemotherapy, 2018 A fast and easy-to-use liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of a novel antifungal drug, olorofim (F901318), a member of the novel class of orotomides, in human plasma and serum was developed and validated.
Philipp Koehler, Martin H J Wiesen
exaly +5 more sources
Correction: Review of the novel antifungal drug olorofim (F901318) [PDF]
BMC Infectious DiseasesYuri Vanbiervliet +5 more
doaj +3 more sources